ID GLE2_CHATD Reviewed; 357 AA.
AC G0SEA3; G0ZGV3;
DT 24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=mRNA export factor GLE2 {ECO:0000305};
DE AltName: Full=Nuclear pore protein GLE2 {ECO:0000305};
DE AltName: Full=Nucleoporin GLE2 {ECO:0000305};
GN Name=GLE2; ORFNames=CTHT_0063040;
OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
OS (Thermochaetoides thermophila).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Thermochaetoides.
OX NCBI_TaxID=759272;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719;
RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA Arumugam M., Bork P., Hurt E.;
RT "Insight into structure and assembly of the nuclear pore complex by
RT utilizing the genome of a eukaryotic thermophile.";
RL Cell 146:277-289(2011).
CC -!- FUNCTION: Functions as a component of the nuclear pore complex (NPC).
CC NPC components, collectively referred to as nucleoporins (NUPs), can
CC play the role of both NPC structural components and of docking or
CC interaction partners for transiently associated nuclear transport
CC factors. It is specifically important for nuclear mRNA export.
CC {ECO:0000250|UniProtKB:P40066}.
CC -!- SUBUNIT: Component of the nuclear pore complex (NPC). NPC constitutes
CC the exclusive means of nucleocytoplasmic transport. NPCs allow the
CC passive diffusion of ions and small molecules and the active, nuclear
CC transport receptor-mediated bidirectional transport of macromolecules
CC such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal
CC subunits across the nuclear envelope. Due to its 8-fold rotational
CC symmetry, all subunits are present with 8 copies or multiples thereof.
CC {ECO:0000250|UniProtKB:P40066, ECO:0000305|PubMed:21784248}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000250|UniProtKB:P40066}. Nucleus membrane
CC {ECO:0000250|UniProtKB:P40066}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P40066}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:P40066}. Nucleus membrane
CC {ECO:0000250|UniProtKB:P40066}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P40066}; Nucleoplasmic side
CC {ECO:0000250|UniProtKB:P40066}. Note=Symmetric distribution.
CC {ECO:0000250|UniProtKB:P40066}.
CC -!- SIMILARITY: Belongs to the WD repeat rae1 family. {ECO:0000305}.
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DR EMBL; GL988046; EGS18280.1; -; Genomic_DNA.
DR EMBL; JF276298; AEL00691.1; -; Genomic_DNA.
DR RefSeq; XP_006696611.1; XM_006696548.1.
DR AlphaFoldDB; G0SEA3; -.
DR SMR; G0SEA3; -.
DR STRING; 759272.G0SEA3; -.
DR TCDB; 1.I.1.1.2; the nuclear pore complex (npc) family.
DR GeneID; 18260342; -.
DR KEGG; cthr:CTHT_0063040; -.
DR eggNOG; KOG0647; Eukaryota.
DR HOGENOM; CLU_038526_1_0_1; -.
DR OMA; EAMDQSI; -.
DR OrthoDB; 121154at2759; -.
DR Proteomes; UP000008066; Unassembled WGS sequence.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10971; MRNA EXPORT FACTOR AND BUB3; 1.
DR PANTHER; PTHR10971:SF11; MRNA EXPORT FACTOR RAE1; 1.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Repeat; Translocation; Transport; WD repeat.
FT CHAIN 1..357
FT /note="mRNA export factor GLE2"
FT /id="PRO_0000433190"
FT REPEAT 28..71
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 76..115
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 117..158
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 160..197
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 256..295
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 357 AA; 39411 MW; 10B48D9A61EC99EF CRC64;
MAGLFGTTTS TTTSTLGDLK NDVELGSPPE DSITDLSFNP NPNDPKDFLA VSSWDKKVRV
YEIAANGQNQ GKVQMEHEGP VFAVDFFKDG TKVISAGADK QAKVLDLASG QAMQVAAHDA
PIRCVKYFEA GGTPMAVTGS WDKTIKYWDF RSATPAGTVQ CQERVYTMDV KENLLVIGTA
DRYIDVINLK EPVKFYKTLQ SPLKWQTRVV SCFTDSQGFA IGSIEGRCAI QYVEDKDQSM
NFSFKCHRDT PQNNVTNVHA VNAISFHPQH GTFSTAGSDG TFHFWDKDAK HRLKGYPNVG
GSITATKFNR NGTIFAYAIS YDWSKGYQGN TANYPTKVML HPVLGDECKP RPSVKKR
//
