ID G0SEX3_CHATD Unreviewed; 986 AA.
AC G0SEX3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Exosome complex exonuclease-like protein {ECO:0000313|EMBL:EGS17989.1};
GN ORFNames=CTHT_0060020 {ECO:0000313|EMBL:EGS17989.1};
OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
OS (Thermochaetoides thermophila).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Thermochaetoides.
OX NCBI_TaxID=759272 {ECO:0000313|Proteomes:UP000008066};
RN [1] {ECO:0000313|EMBL:EGS17989.1, ECO:0000313|Proteomes:UP000008066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719
RC {ECO:0000313|Proteomes:UP000008066};
RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA Arumugam M., Bork P., Hurt E.;
RT "Insight into structure and assembly of the nuclear pore complex by
RT utilizing the genome of a eukaryotic thermophile.";
RL Cell 146:277-289(2011).
CC -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
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DR EMBL; GL988046; EGS17989.1; -; Genomic_DNA.
DR RefSeq; XP_006696320.1; XM_006696257.1.
DR AlphaFoldDB; G0SEX3; -.
DR STRING; 759272.G0SEX3; -.
DR GeneID; 18260040; -.
DR KEGG; cthr:CTHT_0060020; -.
DR eggNOG; KOG2102; Eukaryota.
DR HOGENOM; CLU_002333_5_0_1; -.
DR OMA; VKVHMDS; -.
DR OrthoDB; 945235at2759; -.
DR Proteomes; UP000008066; Unassembled WGS sequence.
DR GO; GO:0000178; C:exosome (RNase complex); IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR CDD; cd09862; PIN_Rrp44-like; 1.
DR Gene3D; 2.40.50.690; -; 1.
DR Gene3D; 2.40.50.700; -; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR041505; Dis3_CSD2.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR002716; PIN_dom.
DR InterPro; IPR001900; RNase_II/R.
DR InterPro; IPR022966; RNase_II/R_CS.
DR InterPro; IPR033771; Rrp44_CSD1.
DR InterPro; IPR033770; RRP44_S1.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR Pfam; PF17849; OB_Dis3; 1.
DR Pfam; PF13638; PIN_4; 1.
DR Pfam; PF00773; RNB; 1.
DR Pfam; PF17216; Rrp44_CSD1; 1.
DR Pfam; PF17215; Rrp44_S1; 1.
DR SMART; SM00670; PINc; 1.
DR SMART; SM00955; RNB; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR SUPFAM; SSF88723; PIN domain-like; 1.
DR PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR PROSITE; PS50126; S1; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:EGS17989.1};
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Hydrolase {ECO:0000313|EMBL:EGS17989.1};
KW Nuclease {ECO:0000313|EMBL:EGS17989.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008066};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 889..983
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
SQ SEQUENCE 986 AA; 111711 MW; 7948BDFF708B0C21 CRC64;
MASLKRSLES DPLAANISSK VYVRSTKSGK VQKIVREVYL RTDIPCSSKL CKSCITGAPR
DAQGRIAPFV LSDQPAGTKA FPQGHYLVPD TNAFLTAMDL FESSAAFYDV IVLQVVLEEL
RNRSLPLYNR LINLTKSEDK RFYVFFNEFR FETHVARLEG ESVNDRNDRA VRKAVAWYAE
HLKKTGKKNV PAVVMLSNDR ANLRKAKEEG IHACSLAEYV SQLPDGDALL DMVPATEEEE
TIKEKRPNEM LYPEYYSMSK MMTGIKNGLL HQGIFNVSPY NYLEGSIRVP AFQKPLLILG
RENINRAIDG DLVVVEVLPK DQWKEPSTQV IEEEAITKNE NPDAEESTDL VSEKERKALQ
EEVKRMHSKT TEGHPQPTAR VVGVIKRNWR QYVGHIDQSS ISQSAQQGRK QDSVFVIPMD
RRIPKIRLRT RQVAELVGKR ILVAIDAWDR SSRHPTGHLI RSLGEMETNA AETEALLLEY
DVQYRPFPKT VLDCLPKEGH DWRVPEDKND PGWRDREDLR HLLICSIDPI GCQDIDDALH
SRPLPNGNFE VGVHIADVSH FVRPNNAMDL EASIRGTTVY LVDKRIDMLP TLLGTDLCSL
KPYVERYAFS VLWELTPDAD IVSVRFTKSV IKSREAFSYE QAQMRVDDGS YQDDLTKSIR
TLLALSRKLK QKRMDAGALS LSSPEVKIHM ESETSDPIDI KTKKHLPTMS LVEEFMLLAN
ISVARKIYEA FPQTAILRRH AAPPKTNFDE LANQLRVKRG LELSVESSKA LADSLDRCVD
PNEPFFNTLV RIMATRCMMA AEYFCSGTQA YPEFRHYGLA SEIYTHFTSP IRRYADLVAH
RQLAAAIGYE AIDPSVRSRG RLEAVCKNIN VRHRNAQLAG RASIAYYVGQ ALKGKAEEED
GFVMKIFSNG FVVLVPRFGI EGLIRLRDLA EPEPQAEYDA ENYVLKTKGS REVTVELFQK
VRVRVSDQKD EATGKRGVKM ELVKTY
//
