ID G0T0T7_RHOT2 Unreviewed; 599 AA.
AC G0T0T7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 13-SEP-2023, entry version 58.
DE SubName: Full=Methylenetetrahydrofolate reductase {ECO:0000313|EMBL:EGU11236.1};
GN ORFNames=RTG_02688 {ECO:0000313|EMBL:EGU11236.1};
OS Rhodosporidium toruloides (strain ATCC 204091 / IIP 30 / MTCC 1151) (Yeast)
OS (Rhodotorula glutinis (strain ATCC 204091)).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX NCBI_TaxID=1001064 {ECO:0000313|EMBL:EGU11236.1, ECO:0000313|Proteomes:UP000006141};
RN [1] {ECO:0000313|EMBL:EGU11236.1, ECO:0000313|Proteomes:UP000006141}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204091 / IIP 30 / MTCC 1151
RC {ECO:0000313|Proteomes:UP000006141};
RX PubMed=24526636; DOI=10.1128/genomeA.00046-14;
RA Paul D., Magbanua Z., Arick M.II., French T., Bridges S.M., Burgess S.C.,
RA Lawrence M.L.;
RT "Genome sequence of the oleaginous yeast Rhodotorula glutinis ATCC
RT 204091.";
RL Genome Announc. 2:E0004614-E0004614(2014).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EGU11236.1}.
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DR EMBL; AEVR02000018; EGU11236.1; -; Genomic_DNA.
DR AlphaFoldDB; G0T0T7; -.
DR HOGENOM; CLU_025841_2_2_1; -.
DR InParanoid; G0T0T7; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000006141; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000006141}.
SQ SEQUENCE 599 AA; 67776 MW; 4E69BD77B34F1502 CRC64;
MVKISDKIKK AEREGRPWWS FEFFPPKTPE GWVNLYDRIE RMQQLGPIFV DITWGAGGST
SEATTNFVKT AHSELGLETC MHLTCTNMPV EMVDKALKAT YDSGCRNILA LRGDPPRGVE
EWKPTEGGFN HAIDLVKHIR KNYGDYFCIG VAGFPEGHPQ SESPEAEIRH FKKKVDAGAD
IVFTQMFYDA EVFIDWGRRL RAAGITIPIV PGIMPIQTFA AFKRRTDFAG TIVPKELWDL
LEPIKDDDAK VREVGTKYVA DMCRKILNAD LGIHGIHCYT MNLSRGTEML LEEMQFVPTA
DRVKPLPWRL SLTQKRRAET TRPIFWSNRQ KSYITRTRDW DEFPNGRWGD ASSPAFGDVD
ALLLALPHKP QDAIKLWGKP HSLGNITALF ARFCRGDLKS LPWSDQPAAK ETTRIAEQLA
RINELGFLTI NSQPRVDGAP SEDPAVGWGP IRGYVYQKAY LEFFCPPELV EPLLELLGDT
PSVTYHAVNK QGDFRSNTAP GPNAVTWGVF PGAEVIQPTV VDSTAFQAWK DEAYELGWQW
AQLYKETAPE TYEVISRIFS EFHLVNIVFN DYRNTDEDAI FKPFFELAHR KGLSVANGH
//
