ID G0VAR2_NAUCC Unreviewed; 1330 AA.
AC G0VAR2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Bud site selection protein 5 {ECO:0008006|Google:ProtNLM};
GN Name=NCAS0B08540 {ECO:0000313|EMBL:CCC68938.1};
GN OrderedLocusNames=NCAS_0B08540 {ECO:0000313|EMBL:CCC68938.1};
OS Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC
OS 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Naumovozyma.
OX NCBI_TaxID=1064592 {ECO:0000313|EMBL:CCC68938.1, ECO:0000313|Proteomes:UP000001640};
RN [1] {ECO:0000313|EMBL:CCC68938.1, ECO:0000313|Proteomes:UP000001640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630
RC {ECO:0000313|Proteomes:UP000001640};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Type strain:CBS 4309;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Naumovozyma castellii.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HE576753; CCC68938.1; -; Genomic_DNA.
DR RefSeq; XP_003675309.1; XM_003675261.1.
DR STRING; 1064592.G0VAR2; -.
DR GeneID; 11526129; -.
DR KEGG; ncs:NCAS_0B08540; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_003150_1_0_1; -.
DR InParanoid; G0VAR2; -.
DR OMA; LYFRNFN; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000001640; Chromosome 2.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR PANTHER; PTHR23113:SF354; BUD SITE SELECTION PROTEIN 5; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001640}.
FT DOMAIN 754..893
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1044..1294
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 127..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1330 AA; 153098 MW; 31E0AEDF10D29006 CRC64;
MNIGKSQSAK GPINKEKENL LSPTRSLNLS PINHLIDDLA SELKEYNTTY QSGMSDSFQN
ITTQDEKKPT TLDHPFTAFS KKRENITSSV YDDSPLITSF KNSNKQTATN SNQDNYVQPQ
YNKNVPTNTL ASNSPMSSIY SPVQTRKTTR PTNAIRSSIL TNKQQLENSE LQNLTLNADD
SIASDANNTL PNTGPSNTFD FDNTLTTITT NNSSPMKPTT AANNTTVDSS DYAYLFIMAV
HSFDTSTLEN ENDKTICLDF DKYDVAFVHN VDESGWGEVT LIKNEKRGWI PFNYFEDTIK
TVKGNKTIDI INSRIPMKLL LSASAQFLLN PQNFRLPGTN SYTFNVDYIN RIRDGVKQLL
EMTNCVSRSN ELVKSKPRIK KARKRLLAEW YNLMIKADSY KQTTSSRRIE KLTAILYQVL
KMSFNFFVTW SHDILEYEKE MATTKSIDPM KPSNTHFNKP NLDIKNLDTI PFAKSRLNEI
HCLLFNYIAI ILGRLDLIEH NPIGCEALEL IVHQIIMLLR ELLYISKSCS FFIQEKYQNG
YENTLDSNLD PLLSLVSDLI STIKDLVTKT IHDDYKSDLG KEKVTSEIYQ YTQDGSRLIN
IICQMTALIS KTVQGVSNYL KLIGDFELDS DRKYPNFKLL KITPADFIKK CSIGLAKNID
YKKLQSSYQM ESVRKKNSEN KNISLSRYST IRAGNSKNEF TYQGTQLLQN TLNENKSFDR
YSIFEKYTVD NDEKSDILTT NDTDILHDEL VRNSSNNIIG GSFRALVIKL TDEIDKADDF
LIFSFLLNFR IFGTPETLIE ILIERFDTEG KRSTTQTYNK SGPYSSSESR IKNRRRIICN
IFNIWMETFW NYTTDFTLLP TMINFFNEGV CEFLPIEGKL LIEVAAKLMN KTSLKRNSNI
IPKGCFDQLK VRSIQPSSTS SILSEKSIAR SSIASSILTL DENLIEEYEL IDPLKQKRDS
FSLELPILNL GNYSLLSKED VQNIERSLDF YKQITNKTKA ETNSLRNINL QTKDIIDNWI
RITIGTTLTP RFDKLQIKNL VSFNALEAAK QLTLLESTLY MEVQPFELIN ENFLQKKKLL
NLSPNINATL NFTNQFTNYV LESILTPNLS IPKRCSRLKG WLRIALSTLY FRNYNSLASI
MIALQSHSLS RLYFLWEDLT EKDIKLYDFL CQIIHPNNNY RVYREKLRIL KSGNNQAPLS
LSKSPLPIVP FFNLFLQDLT FINEGLPDYR NPDSFRPNKI INMDKFFKIT NTLSTVQFFQ
VKYETENVVA NNQRDSFFHL TDQMGVDTRN IKPLPLFQEF ILYEFWYVNT FYTANPDRSY
ELSLQLLPRK
//
