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Database: UniProt
Entry: G0VB16_NAUCC
LinkDB: G0VB16_NAUCC
Original site: G0VB16_NAUCC 
ID   G0VB16_NAUCC            Unreviewed;       282 AA.
AC   G0VB16;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   RecName: Full=uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109};
DE            EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109};
DE   AltName: Full=Hydroxymethylbilane hydrolyase [cyclizing] {ECO:0000256|ARBA:ARBA00032649};
DE   AltName: Full=Uroporphyrinogen-III cosynthase {ECO:0000256|ARBA:ARBA00031702};
GN   Name=NCAS0B00550 {ECO:0000313|EMBL:CCC68139.1};
GN   OrderedLocusNames=NCAS_0B00550 {ECO:0000313|EMBL:CCC68139.1};
OS   Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC
OS   1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Naumovozyma.
OX   NCBI_TaxID=1064592 {ECO:0000313|EMBL:CCC68139.1, ECO:0000313|Proteomes:UP000001640};
RN   [1] {ECO:0000313|EMBL:CCC68139.1, ECO:0000313|Proteomes:UP000001640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630
RC   {ECO:0000313|Proteomes:UP000001640};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT   accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Type strain:CBS 4309;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA   Wolfe K.H.;
RT   "Genome sequence of Naumovozyma castellii.";
RL   Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004772}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000256|ARBA:ARBA00008133}.
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DR   EMBL; HE576753; CCC68139.1; -; Genomic_DNA.
DR   RefSeq; XP_003674516.1; XM_003674468.1.
DR   AlphaFoldDB; G0VB16; -.
DR   STRING; 1064592.G0VB16; -.
DR   GeneID; 11524784; -.
DR   KEGG; ncs:NCAS_0B00550; -.
DR   eggNOG; KOG4132; Eukaryota.
DR   HOGENOM; CLU_051874_0_1_1; -.
DR   InParanoid; G0VB16; -.
DR   OMA; IHGADTG; -.
DR   OrthoDB; 1472480at2759; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000001640; Chromosome 2.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR12390; UROPORPHYRINOGEN III SYNTHASE; 1.
DR   PANTHER; PTHR12390:SF0; UROPORPHYRINOGEN-III SYNTHASE; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001640}.
FT   DOMAIN          39..273
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
SQ   SEQUENCE   282 AA;  31918 MW;  C1A530A58D771726 CRC64;
     MTNEPERSNN SKKLMSGSNK RIIFLKNKTI NHDKYEIEFL SHGYDPVFIP LIEHTNIPNE
     ALTLLKEKEY ISSVNFIIIT SQRTVECLNE CILPVLDAEH KSLLLNKVIY TVGPATAEYL
     QQSGFKNIRG GKEAGNGNIL ADIIISDLQH STEDFLLKNH GPILFFVGQI RKDIILKKLS
     KSDISIREVV VYDTKELQDN VIRFQECVKN SVTNYVVVFS PQGMNEIVDY LKDQPNSSKF
     RIASIGPTTK KYLEEKGLSN VIVSPKPDAV SLLNEIEMHP LK
//
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