ID G0VGN0_NAUCC Unreviewed; 1364 AA.
AC G0VGN0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Guanine nucleotide exchange factor LTE1 {ECO:0008006|Google:ProtNLM};
GN Name=NCAS0F01670 {ECO:0000313|EMBL:CCC70651.1};
GN OrderedLocusNames=NCAS_0F01670 {ECO:0000313|EMBL:CCC70651.1};
OS Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC
OS 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Naumovozyma.
OX NCBI_TaxID=1064592 {ECO:0000313|EMBL:CCC70651.1, ECO:0000313|Proteomes:UP000001640};
RN [1] {ECO:0000313|EMBL:CCC70651.1, ECO:0000313|Proteomes:UP000001640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630
RC {ECO:0000313|Proteomes:UP000001640};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Type strain:CBS 4309;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Naumovozyma castellii.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HE576757; CCC70651.1; -; Genomic_DNA.
DR RefSeq; XP_003677006.1; XM_003676958.1.
DR STRING; 1064592.G0VGN0; -.
DR GeneID; 11527471; -.
DR KEGG; ncs:NCAS_0F01670; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_004883_0_0_1; -.
DR InParanoid; G0VGN0; -.
DR OMA; PFILMYD; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000001640; Chromosome 6.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001640}.
FT DOMAIN 35..169
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1121..1360
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 384..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1364 AA; 155057 MW; 99ED6DA42D0D1803 CRC64;
MSQPMPELGI FSADDYYPVP STSVITYNES RTNKIRKTVS KADIIALITY LSSPIDPVDY
TIFSDFFLIY RDFLSPNELH ELLILRFRWC ILEILENKNV DVEKQKVGEV ALIRTFVLLR
HSILNYFVQD FLPDSHLRYM LLNFLNDNVY QTSPRIVSGS IVNLKRAWIH SAKQTWENIP
FNEPSSVDFN EWLLFEIKDV IQMEEQLKRG SRLSEYAIQG SSSPDFRNRS VLSLYNSTDN
FKLPESLDFN SNRTKQTASM MLYPNDNSNI PKIPIPKGKE PLKITLINDN KNDIRKISHL
SKIAHMSTVI KDVDYPTSPA INRIIPPTPA KKVEFILNSL YIPEDNDETI EDNPRVKSTP
PPIQSSLLQR GAIGLLARWK RNHTRNSRKE KIKTTQSGVN TPISKPDMDN FVKYVISITS
LENTKSHASG EINDMITSKF DILSARTIDE VEYLISLENE LQQKVRGQAN LNNNNLKSIG
LENTMPFEPP KDTANFSAMD NLDLYKTVSS LAQSVISLSN TLNKSTKLKI VNSPSLSALE
RRMVMSSFPA LNGKVSSSSK IGIEDELVIN ITPPRAKNDG PQRLVFHDDG STLSLPQTPT
KSNRKSNIRH SSPLKNVLPN LNEVDLSDSV CSDDESFVST ISYDSLLSSK SFKHKSSRRS
NLYSRPLTFK NEEQTLKKKT ASKNLREFTF ETSKLSLPSP TKSQGSPKAT HIRQQHHLTP
PVSLSPTDPL KMEAEDHLSP LNKLTPQTAI RPASGRISIL RKSLSITQAR RNTYAGPPKA
DLLRDPDFIK KERSLIESEH QLQELQDDLL ERTSLQSSVA TDNLFNSRKN SPKKVTAENK
VRLSTTPSIY SILDDSSLSS GNTSYNDPAR DSMQFTNDKR IDLREVFHNG SVQNVISNDL
SSDAISGLSE LKDNGINGVS NKYLFSPEED NTDLISPGKD VEVLKNKFLK NETFEEESES
IIDGIQEASD EGAMPNVDLD KEKLKDIADI PDDTGSGDPI SIAMMKLEGT YKTNDDDNKT
HEDSSSVQDL IKEVEMLNLK KLPTFPKSPL EKRKSLMIER RRQTIMNIPF TPQNSEEGLA
IEDKCVSPLQ VQTLVMNYEV QDSSLQISNN EHHIPFILMY DSKSIAEQMT LIEKELLSEI
DWKDLLNLKI QYKGKAVTSW LQLLIQNETL SGVDLAIARF NLTVDWIVSE ITLTRDVKMR
RNTIQRFIHV AQYCREFQNY NTLMEIILAL SSIVVQKFTD AWRLIEPGDM LLWEELKHIP
SLDRNYSTIR NLLNSLDPKK GCIPFIVVYL SDLSLNSEKR NWIVDRKVVN YHKFETSVQI
VKNFIQRVQW AKFYNIEVDH ELLSKCVYIT SLTNKEIDEL AALK
//