ID G0WDR5_NAUDC Unreviewed; 1007 AA.
AC G0WDR5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2012, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Sodium/calcium exchanger membrane region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=NDAI0G01500 {ECO:0000313|EMBL:CCD25926.2};
GN OrderedLocusNames=NDAI_0G01500 {ECO:0000313|EMBL:CCD25926.2};
OS Naumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC
OS 0211 / NRRL Y-12639) (Saccharomyces dairenensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Naumovozyma.
OX NCBI_TaxID=1071378 {ECO:0000313|EMBL:CCD25926.2, ECO:0000313|Proteomes:UP000000689};
RN [1] {ECO:0000313|EMBL:CCD25926.2, ECO:0000313|Proteomes:UP000000689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639
RC {ECO:0000313|Proteomes:UP000000689};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000256|ARBA:ARBA00008170}.
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DR EMBL; HE580273; CCD25926.2; -; Genomic_DNA.
DR RefSeq; XP_003671169.2; XM_003671121.2.
DR AlphaFoldDB; G0WDR5; -.
DR STRING; 1071378.G0WDR5; -.
DR GeneID; 11497322; -.
DR KEGG; ndi:NDAI_0G01500; -.
DR eggNOG; KOG1397; Eukaryota.
DR HOGENOM; CLU_001583_0_0_1; -.
DR OMA; PQWDMIT; -.
DR OrthoDB; 8346at2759; -.
DR Proteomes; UP000000689; Chromosome 7.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProt.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IEA:UniProt.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004713; CaH_exchang.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR InterPro; IPR005185; YccF.
DR PANTHER; PTHR31503:SF10; CATION_H+ EXCHANGER PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
DR Pfam; PF03733; YccF; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000689};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 265..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 450..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 589..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 617..640
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..673
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 685..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 842..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 877..899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 911..934
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 955..972
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..997
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 262..316
FT /note="Inner membrane component"
FT /evidence="ECO:0000259|Pfam:PF03733"
FT DOMAIN 589..703
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 840..996
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 388..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 114231 MW; B0E79F9315F2CF1C CRC64;
MSREPDHVRR VFSVDDDPHE VENDVRYLEG LHDGLKYALQ NKSITPQSPA VEITSQSKNS
SAPDLLSPAI SNHSQHLKLK KKLIIKYNYN HLTAHSPTTI TTRPSNFLKK KNSSRLSTLN
SPKIRSNNTV GADYFTNKHN HIHDHTDFSE ESRDRFIIHN PPHNNTGHDL LIEELDPADA
YNPDNDNNND DMDEDIEDRI SMASSLESFT LRERQDAINK THPFGIRIWK PALYKKKRSV
QKAADEDIHE TQLKMITWPV HISNIIWSFT VGLFLASLFS LGGIIVAILG LFTKSAREYS
IVCFRLARYL FLPFGKVVYL IADEHYLEED NQEGISVNQF YKWVTSYSNR LFFHESQANN
NSLNDNTHPS YGSIHNFMTH QSKRLPTLPA RAGDRQSSSS STPMIPHANS QVTTNLPAPL
PNNPESQNQI NSTSSQRRFF GRGKWTCGRL IFYFCFHLFL QPFVLIFALL SWLFVFTIPM
SNILWNLMYH CRKHPLALGF KNIKNSNANS NPIIKIYNNG SSDDSLANNK SILLCTFRCA
GWHYYKFTVD GTNIIVVNLI AIVFFTIFDF YLLKNSWHFR FWFTDESTIF MLCLTSIIPL
AFYIGQAVAS ISAQTSMGVG AVINAFFSTI VEIFLYCVAL QQRKGPLVEG SMIGSILGAV
LLLPGLSMCG GAWNRKTQRY NPASAGVSSA LLIFSMLVMF VPTILYDVYG GYIVKCEDGF
EQPISLKTVM MPLATSSNCS FYHPPLEFDR MYTNVIQPMS VSCAIVLFLA YTIGLWFTLR
THAAMIWHLP ISDPQKETPI NVGINSEQNS ILLQHPNEIA AHTEPNSGGH DAPNWSRTKS
TWILLVATLL YAVIAEILVA CVDSVLEDFP SLNPKFLGLT IFALVPNTTE FLNAISFAIH
GNVALSMEIG SAYALQVCLL QIPALVIYSI WYTWSWDRSM INIREQMFSM IFPRWDLIAS
MGSVFLFTYL YAEGKSNYFK GSMLILLYVI VILGFFFQDV LTNWKWE
//
