ID G0XTN0_COWPX Unreviewed; 227 AA.
AC G0XTN0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Thymidylate kinase {ECO:0000256|ARBA:ARBA00017144};
DE EC=2.7.4.9 {ECO:0000256|ARBA:ARBA00012980};
DE AltName: Full=dTMP kinase {ECO:0000256|ARBA:ARBA00029962};
GN Name=CPXV186 {ECO:0000313|EMBL:AGY97129.1};
GN ORFNames=CPXV_FIN2000_MAN_175 {ECO:0000313|EMBL:ADZ29292.1},
GN CPXV_GER1998_2_175 {ECO:0000313|EMBL:ADZ30149.1};
OS Cowpox virus (CPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10243 {ECO:0000313|EMBL:ADZ29292.1, ECO:0000313|Proteomes:UP000113999};
OH NCBI_TaxID=10129; Apodemus sylvaticus (European woodmouse).
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH NCBI_TaxID=10090; Mus musculus (Mouse).
OH NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN [1] {ECO:0000313|EMBL:ADZ29292.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Finland_2000_MAN {ECO:0000313|EMBL:ADZ29292.1}, and
RC Germany_1998_2 {ECO:0000313|EMBL:ADZ30149.1};
RA Sammons S.A., Carroll D.S., Meyer H.;
RL Submitted (OCT-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000113999, ECO:0000313|Proteomes:UP000171958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Finland_2000_MAN {ECO:0000313|EMBL:ADZ29292.1}, and
RC Germany_1998_2 {ECO:0000313|EMBL:ADZ30149.1};
RA Carroll D.S., Emerson G.L., Li Y., Sammons S., Olson V., Frace M.,
RA Nakazawa Y., Czerny C.P., Tryland M., Kolodziejek J., Nowotny N.,
RA Olsen-Rasmussen M., Khristova M., Govil D., Karem K., Damon I.K., Meyer H.;
RT "Chasing Jenner's Vaccine: Revisiting Cowpox Virus Classification.";
RL PLoS ONE 6:E23086-E23086(2011).
RN [3] {ECO:0000313|Proteomes:UP000097203, ECO:0000313|Proteomes:UP000097445}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BeaBer04/1 {ECO:0000313|EMBL:AGY97129.1}, CatBer07/1
RC {ECO:0000313|EMBL:AGY99481.1}, CatPot07/1
RC {ECO:0000313|EMBL:AGZ00339.1}, HumBer07/1
RC {ECO:0000313|EMBL:AGZ00968.1}, HumLan08/1
RC {ECO:0000313|EMBL:AGY97344.1}, HumMag07/1
RC {ECO:0000313|EMBL:AGY97998.1}, JagKre08/1
RC {ECO:0000313|EMBL:AGY98418.1}, JagKre08/2
RC {ECO:0000313|EMBL:AGY98634.1}, MonKre08/4
RC {ECO:0000313|EMBL:AGY99069.1}, and RatHei09/1
RC {ECO:0000313|EMBL:AGY99909.1};
RA Dabrowski P.W., Radonic A., Kurth A., Nitsche A.;
RT "Genome-wide comparison of cowpoxviruses reveals a new clade related to
RT Variola virus.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:SNB50548.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ger/2010/Cat {ECO:0000313|EMBL:SNB50548.1}, Ger/2012/Alpaca
RC {ECO:0000313|EMBL:SNB50661.1}, Ger/2014/Cat1
RC {ECO:0000313|EMBL:SNB58018.1}, Ger/2014/Cat2
RC {ECO:0000313|EMBL:SNB56897.1}, Ger/2015/Cat2
RC {ECO:0000313|EMBL:SNB72221.1}, Ger/2015/Cat4
RC {ECO:0000313|EMBL:SNB50834.1}, Ger/2015/Human1
RC {ECO:0000313|EMBL:SNB53571.1}, and Ger/2017/Alpaca2
RC {ECO:0000313|EMBL:SPQ84398.1};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:SPQ84398.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ger/2017/Alpaca2 {ECO:0000313|EMBL:SPQ84398.1};
RG IVD NGS Lab;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:SPN68305.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Ger/2015/Human2 {ECO:0000313|EMBL:SPN69146.1},
RC Ger/2015/Prairie-dog {ECO:0000313|EMBL:SPN68866.1}, Ger/2017/Alpaca1
RC {ECO:0000313|EMBL:SPN68584.1}, and Ger/2017/common vole FMEimka
RC {ECO:0000313|EMBL:SPN68305.1};
RA Go L.Y., Mitchell J.A.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + dTMP = ADP + dTDP; Xref=Rhea:RHEA:13517,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58369, ChEBI:CHEBI:63528,
CC ChEBI:CHEBI:456216; EC=2.7.4.9;
CC Evidence={ECO:0000256|ARBA:ARBA00001008};
CC -!- PATHWAY: Pyrimidine metabolism; dTTP biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004992}.
CC -!- SIMILARITY: Belongs to the thymidylate kinase family.
CC {ECO:0000256|ARBA:ARBA00009776}.
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DR EMBL; HQ420893; ADZ29292.1; -; Genomic_DNA.
DR EMBL; HQ420897; ADZ30149.1; -; Genomic_DNA.
DR EMBL; KC813491; AGY97129.1; -; Genomic_DNA.
DR EMBL; KC813492; AGY97344.1; -; Genomic_DNA.
DR EMBL; KC813495; AGY97998.1; -; Genomic_DNA.
DR EMBL; KC813497; AGY98418.1; -; Genomic_DNA.
DR EMBL; KC813498; AGY98634.1; -; Genomic_DNA.
DR EMBL; KC813500; AGY99069.1; -; Genomic_DNA.
DR EMBL; KC813502; AGY99481.1; -; Genomic_DNA.
DR EMBL; KC813504; AGY99909.1; -; Genomic_DNA.
DR EMBL; KC813506; AGZ00339.1; -; Genomic_DNA.
DR EMBL; KC813509; AGZ00968.1; -; Genomic_DNA.
DR EMBL; LT896729; SNB50548.1; -; Genomic_DNA.
DR EMBL; LT896726; SNB50661.1; -; Genomic_DNA.
DR EMBL; LT896731; SNB50834.1; -; Genomic_DNA.
DR EMBL; LT896720; SNB53571.1; -; Genomic_DNA.
DR EMBL; LT896725; SNB56897.1; -; Genomic_DNA.
DR EMBL; LT896723; SNB58018.1; -; Genomic_DNA.
DR EMBL; LT896727; SNB72221.1; -; Genomic_DNA.
DR EMBL; LT993228; SPN68305.1; -; Genomic_DNA.
DR EMBL; LT993230; SPN68584.1; -; Genomic_DNA.
DR EMBL; LT993231; SPN68866.1; -; Genomic_DNA.
DR EMBL; LT993232; SPN69146.1; -; Genomic_DNA.
DR EMBL; LT896732; SPQ84398.1; -; Genomic_DNA.
DR UniPathway; UPA00575; -.
DR Proteomes; UP000097203; Genome.
DR Proteomes; UP000097445; Genome.
DR Proteomes; UP000098423; Genome.
DR Proteomes; UP000101132; Genome.
DR Proteomes; UP000113999; Genome.
DR Proteomes; UP000115255; Genome.
DR Proteomes; UP000137723; Genome.
DR Proteomes; UP000151407; Genome.
DR Proteomes; UP000159199; Genome.
DR Proteomes; UP000163863; Genome.
DR Proteomes; UP000171958; Genome.
DR Proteomes; UP000173670; Genome.
DR Proteomes; UP000267117; Genome.
DR Proteomes; UP000269429; Genome.
DR Proteomes; UP000270432; Genome.
DR Proteomes; UP000271295; Genome.
DR Proteomes; UP000272949; Genome.
DR Proteomes; UP000273263; Genome.
DR Proteomes; UP000276188; Genome.
DR Proteomes; UP000277211; Genome.
DR Proteomes; UP000277503; Genome.
DR Proteomes; UP000278652; Genome.
DR Proteomes; UP000279758; Genome.
DR Proteomes; UP000280293; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004798; F:thymidylate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR GO; GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039430; Thymidylate_kin-like_dom.
DR InterPro; IPR018095; Thymidylate_kin_CS.
DR InterPro; IPR018094; Thymidylate_kinase.
DR NCBIfam; TIGR00041; DTMP_kinase; 1.
DR PANTHER; PTHR10344; THYMIDYLATE KINASE; 1.
DR PANTHER; PTHR10344:SF1; THYMIDYLATE KINASE; 1.
DR Pfam; PF02223; Thymidylate_kin; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:ADZ29292.1};
KW Transferase {ECO:0000313|EMBL:ADZ29292.1}.
FT DOMAIN 32..204
FT /note="Thymidylate kinase-like"
FT /evidence="ECO:0000259|Pfam:PF02223"
SQ SEQUENCE 227 AA; 26177 MW; 745886CFDCB56249 CRC64;
MTYIFIFSFI IRINCKKYVR FTKMSRGALI VFEGLDKSGK TTQCMNIMES IPSNTIKYLN
FPQRSTVTGK MIDDYLTRKK TYNDHIVNLL FCANRWEFAS FIQEQLEQGI TLIVDRYAFS
GVAYAAAKGA SMTLSKSYES GLPKPDLVIF LESGSKEINR NVGEEIYEDV EFQQKVLQEY
KKMIEEGDIH WQIISSEFEE DVKKELIKNI VIEAIHTVTG PVGQLWM
//
