ID G1DUR4_9CAUD Unreviewed; 389 AA.
AC G1DUR4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=Cytosine-specific methyltransferase {ECO:0000256|RuleBase:RU000417};
DE EC=2.1.1.37 {ECO:0000256|RuleBase:RU000417};
GN Name=70 {ECO:0000313|EMBL:AEJ93254.1};
GN ORFNames=SHILAN_70 {ECO:0000313|EMBL:AEJ93254.1};
OS Mycobacterium phage ShiLan.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Gracegardnervirinae; Cheoctovirus; Mycobacterium virus Shilan.
OX NCBI_TaxID=1036616 {ECO:0000313|EMBL:AEJ93254.1, ECO:0000313|Proteomes:UP000008402};
RN [1] {ECO:0000313|EMBL:AEJ93254.1, ECO:0000313|Proteomes:UP000008402}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22282335; DOI=10.1128/JVI.06870-11;
RG the Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science Program;
RG the KwaZulu-Natal Research Institute for Tuberculosis and HIV Mycobacterial Genetics Course Students;
RG the Phage Hunters Integrating Research and Education Program;
RA Hatfull G.F.;
RT "Complete Genome Sequences of 138 Mycobacteriophages.";
RL J. Virol. 86:2382-2384(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC Evidence={ECO:0000256|RuleBase:RU000417};
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
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DR EMBL; JN020143; AEJ93254.1; -; Genomic_DNA.
DR REBASE; 682814; M.MphSLORF70P.
DR OrthoDB; 8328at10239; -.
DR Proteomes; UP000008402; Genome.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0099018; P:evasion by virus of host restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR018117; C5_DNA_meth_AS.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR46098; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR46098:SF1; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00094; C5_MTASE_1; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Inhibition of host innate immune response by virus
KW {ECO:0000256|ARBA:ARBA00033479};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016};
KW Restriction-modification system evasion by virus
KW {ECO:0000256|ARBA:ARBA00033479};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Viral immunoevasion {ECO:0000256|ARBA:ARBA00033479}.
FT REGION 160..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 247..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 72
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 389 AA; 41865 MW; 39BBEFC7F5E257B2 CRC64;
MKIGSLFSGA GGLDMAVEHV FNSHVVWQCE YDTAAAKVLA HRYPNIPNCG DVTAINWDSL
DRVDILCGGY PCQPFSAAGQ RKGTEDERHL WPYFAEAIRR IRPRYVVLEN VAGHRSMGFD
TVLGDLASVG YDAQWCSVRA SDVGAPHRRE RVFVLATPSD ASDATADRQR SRTQLGQGSA
DAADANLWSV AARIGRGELL LPTPSAADGD GGHLTRSGER GDELLLPGVA RAYGNGELLP
TPNAQDGNGG GRYNSAGHQS TLPGTVRLLP TPRKSDGDGG PNPLHRSERM DDVETRIIRC
AGQWGKYAPA IAHWEAVTRP APTPTEPNRN GNPRLAPAFS EWMMGWPAGW VTEVPGISRN
DQLRIIGNGV VPQQAAAALR WLLSVEVAA
//
