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Database: UniProt
Entry: G1K2N7_DANRE
LinkDB: G1K2N7_DANRE
Original site: G1K2N7_DANRE 
ID   G1K2N7_DANRE            Unreviewed;       254 AA.
AC   G1K2N7; A0A8M2B8B3;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   RecName: Full=Post-GPI attachment to proteins factor 2 {ECO:0000256|ARBA:ARBA00016871};
GN   Name=frag1 {ECO:0000313|RefSeq:XP_005161358.1};
GN   Synonyms=wu:fc51g11 {ECO:0000313|RefSeq:XP_005161358.1}, zgc:101568
GN   {ECO:0000313|RefSeq:XP_005161358.1};
GN   OrderedLocusNames=pgap2 {ECO:0000313|Ensembl:ENSDARP00000065502,
GN   ECO:0000313|RefSeq:XP_005161358.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-050320-119};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000065502};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000065502}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000065502};
RG   Ensembl;
RL   Submitted (AUG-2011) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000065502}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000065502};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [3] {ECO:0000313|RefSeq:XP_005161358.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005161358.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC       maturation. Required for stable expression of GPI-anchored proteins at
CC       the cell surface. {ECO:0000256|ARBA:ARBA00024944}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Golgi apparatus membrane
CC       {ECO:0000256|ARBA:ARBA00004653}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004653}.
CC   -!- SIMILARITY: Belongs to the PGAP2 family.
CC       {ECO:0000256|ARBA:ARBA00007414}.
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DR   EMBL; CR391971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005161358.1; XM_005161301.3.
DR   Ensembl; ENSDART00000065503; ENSDARP00000065502; ENSDARG00000044596.
DR   Ensembl; ENSDART00000065503.6; ENSDARP00000065502.4; ENSDARG00000044596.7.
DR   GeneID; 541417; -.
DR   CTD; 27315; -.
DR   ZFIN; ZDB-GENE-050320-119; pgap2.
DR   HOGENOM; CLU_061191_1_0_1; -.
DR   OMA; HYREHIR; -.
DR   OrthoDB; 3668913at2759; -.
DR   PhylomeDB; G1K2N7; -.
DR   TreeFam; TF314112; -.
DR   Bgee; ENSDARG00000044596; Expressed in mature ovarian follicle and 24 other cell types or tissues.
DR   GO; GO:0000139; C:Golgi membrane; IEA:InterPro.
DR   InterPro; IPR019402; Frag1/DRAM/Sfk1.
DR   InterPro; IPR039545; PGAP2.
DR   PANTHER; PTHR12892; FGF RECEPTOR ACTIVATING PROTEIN 1; 1.
DR   PANTHER; PTHR12892:SF11; POST-GPI ATTACHMENT TO PROTEINS FACTOR 2; 1.
DR   Pfam; PF10277; Frag1; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        20..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        111..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        145..168
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        180..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   254 AA;  29060 MW;  B28C939B9135F5A5 CRC64;
     MQQVPYGSVD RDKPLIRVPF TRLAVITVCL PLLGLVACIV LAMLYHYNDA TYTHCQVPNY
     LPSISAAISL TPERYIWRFS IGLHSAPRFL VAAAYLSFYR GRFSRRLTEQ LLSGFTFLLA
     LSENVGLLLL TYVSSTETYS VHKSGFILFI GSSLFHMLCT CKLWSLIVKY SISSEEMMSY
     WFKLRLFLFN GGCCVLAVYF YRRHNTYCEE GIYTCFAVCE YLVVLSNMAF HMTAYWDFGG
     KEVMVATPPE GKHF
//
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