ID G1K3E4_XENTR Unreviewed; 370 AA.
AC G1K3E4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Serine/threonine-protein kinase PLK1 {ECO:0000313|Ensembl:ENSXETP00000022754};
GN Name=plk1 {ECO:0000313|Ensembl:ENSXETP00000022754};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000022754};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000022754}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000022754};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000022754}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2011) to UniProtKB.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00006936}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G1K3E4; -.
DR Ensembl; ENSXETT00000022754; ENSXETP00000022754; ENSXETG00000010344.
DR AGR; Xenbase:XB-GENE-941540; -.
DR Xenbase; XB-GENE-941540; plk1.
DR HOGENOM; CLU_000288_46_1_1; -.
DR TreeFam; TF101089; -.
DR Bgee; ENSXETG00000010344; Expressed in 2-cell stage embryo and 8 other cell types or tissues.
DR GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR Gene3D; 3.40.50.12470; -; 1.
DR Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR InterPro; IPR032106; 2-oxogl_dehyd_N.
DR InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR InterPro; IPR031717; KGD_C.
DR InterPro; IPR042179; KGD_C_sf.
DR PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR PANTHER; PTHR23152:SF5; 2-OXOGLUTARATE DEHYDROGENASE-LIKE, MITOCHONDRIAL; 1.
DR Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR Pfam; PF16870; OxoGdeHyase_C; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT DOMAIN 43..81
FT /note="2-oxoglutarate dehydrogenase E1 component N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16078"
FT DOMAIN 215..360
FT /note="Multifunctional 2-oxoglutarate metabolism enzyme C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16870"
SQ SEQUENCE 370 AA; 41842 MW; DF4CE081CAAFD220 CRC64;
MSHLRTVAAK LKPYCTGLLV KHSSTPRTLP QRCSVYSSGA KEPFLSGTNS SYVEEMYYAW
LENPKSVHKS WDIFFQSADA GTPQCETRGV PSLTGIESKL QSLSSQGLAT APAKAEKIVE
EHLAVQSLIR AYQIRGHHVA QLDPLGILDA DLDSFVPSDL ITTLDKLGFY GLHEGDLDKV
FPSYFHVLRR QILLPFRKPL IIFTPKSLLR HPEAKSSFDD MNTGTNFQRV IPENGAASHN
PQAVKRVIFC TGKIYYELVK ERHNKGLDNQ VAITRLEQLS PFPFDLVKQE AEKYATSELV
WCQEEHKNMG YYDYVKARFL TILNHARPVW YVGRDPAAAP ATGNKNTHHV ELKRFLDVAF
NLQYFEGKPF
//
