ID G1K3J2_XENTR Unreviewed; 626 AA.
AC G1K3J2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=procollagen-proline 3-dioxygenase {ECO:0000256|ARBA:ARBA00012262};
DE EC=1.14.11.7 {ECO:0000256|ARBA:ARBA00012262};
GN Name=tnfaip1 {ECO:0000313|Ensembl:ENSXETP00000042121};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000042121};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000042121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000042121};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000042121}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2011) to UniProtKB.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC -!- SIMILARITY: Belongs to the leprecan family.
CC {ECO:0000256|ARBA:ARBA00006487}.
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DR AlphaFoldDB; G1K3J2; -.
DR Ensembl; ENSXETT00000042121; ENSXETP00000042121; ENSXETG00000019443.
DR AGR; Xenbase:XB-GENE-943703; -.
DR Xenbase; XB-GENE-943703; tnfaip1.
DR HOGENOM; CLU_060008_0_0_1; -.
DR TreeFam; TF315649; -.
DR Bgee; ENSXETG00000019443; Expressed in 2-cell stage embryo and 14 other cell types or tissues.
DR ExpressionAtlas; G1K3J2; baseline.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0019797; F:procollagen-proline 3-dioxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0032963; P:collagen metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR039575; P3H.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR14049; LEPRECAN 1; 1.
DR PANTHER; PTHR14049:SF1; PROLYL 3-HYDROXYLASE 2; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR SMART; SM00702; P4Hc; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 474..588
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 626 AA; 72218 MW; 890E553E4DEDF2C4 CRC64;
MSTNVIIITC NRLYIICICL LIALYQSSAA TSLCKGFHAP YDLLYDSGIE AYYKNDYQKV
VYYMELAISN YSQLRQTKLN CRLGCKHRYP LETSSAFWDI SFFTVILSRA ACVKQCEEGS
LGAVSRHKVS EETKGEFYRR MPYNFLQRAY FKLNQMDKAA EAAHTFFMAN PEHMEVQENL
KNYQIKSDTH LVDRERRPHM DDYHSGVKLY DAEQYKLAIE KFERALKGYY RADNECRALC
WGPQKFEEYE YIDYKATLYE AIADHYIQIL ACEHECVREL ATRPGRLSPI ENFLPLHYDF
LQFSYYREGD TLKALECAKS YLLFHPGDAD VLENVSFYES QLPEYLDPDD IQPREVSIRG
SLIYDEVKLM HSSDFLNGTQ RVQLDNVISE QECQDLQTVA NMITLAGDGY RGKTSPHTPN
EKFEGATVLK ALKFGYEGRI PMNSARLFYD VSEKARRIVQ SYFMLNTTLY FSYTHLVCRT
ALQGQQDNRN DLSHPIHADN CLLDPEANEC WKESPAYTFR DYSALLYLNG DFDGGEFVFT
EMDAKTITAS IKPKCGRLVG FSSGGENPHG VKAVTRGQRC AVALWFTLDP LYRELERLQA
DEVIRTLDQN IQSSGIDMNI NPRDEL
//