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Database: UniProt
Entry: G1K877_ANOCA
LinkDB: G1K877_ANOCA
Original site: G1K877_ANOCA 
ID   G1K877_ANOCA            Unreviewed;       393 AA.
AC   G1K877;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   16-OCT-2019, entry version 57.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000000046};
GN   Name=KCNJ11 {ECO:0000313|Ensembl:ENSACAP00000000046};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000000046, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000000046, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000000046};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000000046}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_003214852.1; XM_003214804.2.
DR   STRING; 28377.ENSACAP00000000046; -.
DR   Ensembl; ENSACAT00000000047; ENSACAP00000000046; ENSACAG00000000047.
DR   GeneID; 100557606; -.
DR   KEGG; acs:100557606; -.
DR   CTD; 3767; -.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00970000193347; -.
DR   InParanoid; G1K877; -.
DR   KO; K05004; -.
DR   OMA; GMYAVDY; -.
DR   OrthoDB; 956263at2759; -.
DR   TreeFam; TF313676; -.
DR   Proteomes; UP000001646; Chromosome 1.
DR   Bgee; ENSACAG00000000047; Expressed in 3 organ(s), highest expression level in skeletal muscle tissue.
DR   GO; GO:0008282; C:inward rectifying potassium channel; IEA:Ensembl.
DR   GO; GO:0030315; C:T-tubule; IEA:Ensembl.
DR   GO; GO:0030506; F:ankyrin binding; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR   GO; GO:0015272; F:ATP-activated inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
DR   GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0050877; P:nervous system process; IEA:Ensembl.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003279; K_chnl_inward-rec_Kir6.2.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF44; PTHR11767:SF44; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01332; KIR62CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     73     94       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    152    176       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       37    181       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      189    360       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   SITE        168    168       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   393 AA;  43738 MW;  4C9928B2AE6AAC14 CRC64;
     MLSRKGILPE EYVLTRLVEA VPEQARYRAR ERRARFVGKN GACNVAHKNI REQGRFLQDV
     FTTLVDLKWS HTLLIFTLSF LCSWLLFAMI WWLLAFAHGD LDHSTRGGGD PGDGFVPCVT
     QLHSFTSAFL FSIEVQVTIG FGGRMATEEC PAAILVLIVQ NISGLIINAI MLGCIFMKTA
     QAHRRAETLI FSKHAVVAVR GGRLCFMLRV GDLRKSMIIS ASIRMQVVRK TTSPEGEVVP
     LNQVDIQLEN PVGGNSIFLV SPLIICHTID SSSPLYDLAP SQLLHHEDLE VIVILEGVVE
     TTGITTQART SYLADEILWG HRFVPIVTEE DGQYSVDYSK FGNTVKVPTP NCTARQLEED
     SSIMKTVVLS PKATIRKRSV RLKPKFTISD EPS
//
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