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Database: UniProt
Entry: G1KBU1_ANOCA
LinkDB: G1KBU1_ANOCA
Original site: G1KBU1_ANOCA 
ID   G1KBU1_ANOCA            Unreviewed;       401 AA.
AC   G1KBU1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   11-DEC-2019, entry version 53.
DE   SubName: Full=NHL repeat containing E3 ubiquitin protein ligase 1 {ECO:0000313|Ensembl:ENSACAP00000003277};
GN   Name=NHLRC1 {ECO:0000313|Ensembl:ENSACAP00000003277};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000003277, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000003277, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000003277};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000003277}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   RefSeq; XP_003219833.1; XM_003219785.3.
DR   STRING; 28377.ENSACAP00000003277; -.
DR   Ensembl; ENSACAT00000003360; ENSACAP00000003277; ENSACAG00000003390.
DR   GeneID; 100552850; -.
DR   KEGG; acs:100552850; -.
DR   CTD; 378884; -.
DR   eggNOG; ENOG410ITF2; Eukaryota.
DR   eggNOG; ENOG410ZMHC; LUCA.
DR   GeneTree; ENSGT00730000111361; -.
DR   InParanoid; G1KBU1; -.
DR   KO; K10602; -.
DR   OMA; WGTLINP; -.
DR   OrthoDB; 711255at2759; -.
DR   TreeFam; TF331018; -.
DR   Proteomes; UP000001646; Chromosome 4.
DR   Bgee; ENSACAG00000003390; Expressed in 4 organ(s), highest expression level in heart.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0006914; P:autophagy; IEA:Ensembl.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:Ensembl.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IEA:Ensembl.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   GO; GO:0010468; P:regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:Ensembl.
DR   GO; GO:1903076; P:regulation of protein localization to plasma membrane; IEA:Ensembl.
DR   GO; GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl.
DR   Gene3D; 2.120.10.30; -; 2.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR013017; NHL_repeat_subgr.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF14634; zf-RING_5; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS51125; NHL; 6.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   DOMAIN          26..72
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REPEAT          122..165
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          169..212
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          223..253
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          268..308
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          331..357
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT   REPEAT          368..401
FT                   /note="NHL"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
SQ   SEQUENCE   401 AA;  43604 MW;  FB9CD75201420A1A CRC64;
     MSTKTSKKIQ TMTELVDQTE NCLLECKVCF EKYNQQKKHR PRNLPCGHVM CLECVMSLTH
     PRTFKLECPF CRRACKSSET SDCLPLLHLM EILSLPLNNA PVPGSSIGRT TEDVSTPASQ
     ALTFSLSFGG WGTLINPTGI AVCQRSGCAA VVHDGKKRIK LFTFTGNCMQ QFGERGQAGN
     DIRYPNDITA TLDGHIVITD SGDGSVKVFD FNGRGKLVIS ESFCLPWGLD TTPQNDIIMT
     DSKAGTLYCL SADFKKGELK GVRKLHSNLC NPRKVAVSQA SGAIAVIEHL MVKGPSYGST
     RVKVFSADMQ VLGQVDSFGL NLVFPIKIYA SGVTFNKEGH IVVSDAYNQA VFSLGKPEEF
     PVCKPVVTQG LSYPLALTFT PDNSLIVLDG GDHSLKVYTA S
//
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