ID   G1KF34_ANOCA            Unreviewed;       505 AA.
AC   G1KF34;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 3.
DT   27-MAR-2024, entry version 63.
DE   RecName: Full=Centrosomal protein 57kDa-like protein 1 {ECO:0000256|ARBA:ARBA00041218};
DE   AltName: Full=Cep57-related protein {ECO:0000256|ARBA:ARBA00042578};
GN   Name=CEP57L1 {ECO:0000313|Ensembl:ENSACAP00000006046.4};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006046.4, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000006046.4, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000006046.4,
RC   ECO:0000313|Proteomes:UP000001646};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000006046.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000256|ARBA:ARBA00004300}.
CC   -!- SIMILARITY: Belongs to the translokin family.
CC       {ECO:0000256|ARBA:ARBA00008179}.
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DR   AlphaFoldDB; G1KF34; -.
DR   Ensembl; ENSACAT00000006180.4; ENSACAP00000006046.4; ENSACAG00000006164.4.
DR   eggNOG; ENOG502QTVF; Eukaryota.
DR   GeneTree; ENSGT00530000063695; -.
DR   InParanoid; G1KF34; -.
DR   TreeFam; TF329178; -.
DR   Proteomes; UP000001646; Chromosome 1.
DR   Bgee; ENSACAG00000006164; Expressed in dewlap and 13 other cell types or tissues.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0043015; F:gamma-tubulin binding; IEA:InterPro.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   Gene3D; 1.20.58.90; -; 1.
DR   InterPro; IPR025913; Cep57_CLD.
DR   InterPro; IPR024957; Cep57_MT-bd_dom.
DR   PANTHER; PTHR19336:SF10; CENTROSOMAL PROTEIN CEP57L1; 1.
DR   PANTHER; PTHR19336; UNCHARACTERIZED DUF1167; 1.
DR   Pfam; PF14073; Cep57_CLD; 1.
DR   Pfam; PF06657; Cep57_MT_bd; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT   DOMAIN          84..261
FT                   /note="Cep57 centrosome localisation"
FT                   /evidence="ECO:0000259|Pfam:PF14073"
FT   DOMAIN          359..428
FT                   /note="Cep57 centrosome microtubule-binding"
FT                   /evidence="ECO:0000259|Pfam:PF06657"
FT   REGION          265..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          82..130
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          219..246
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        285..301
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   505 AA;  57564 MW;  5C4B1EB16623D9A1 CRC64;
     MIYVSLHLRI LTGSFMADLP RYRFDCNRHY GEWGTGSSVM ESFDSASKHS YIGSFLQPPV
     NIRSGLELKK KTIPKDIPAP NNQALVTALR TLQEKIHRLE LERSQAEDDL NALSREAAQY
     KRAMQHESNE KDKTHGKVMQ ERKDVSIQLG AAQTRCSLLE KQLDYMRRMV VSAELEKKQV
     LEQQIQLQKE KDQDQVELCA KLDKLEILEK ECWRLTSTQK TAEEKIKHLE QKLQEEQHQR
     KLIQDKAAQL QTGLEMNRIL LSSISPQKDT KKKCKKKKVV KNNPDSPKTH GSQPSPQTGV
     LPFVAGKSAS SSHSVVANVQ SVLHMMKYRS PCVTSHYSEQ AEKRVSRRAV LGRPSSCTTS
     SSATDSLSDL LLVMQDELGQ MSFEHQELLK QIQETQDQDM REDLERELDC LVKHMEIKGE
     QISKLKKHQE HVFKMRRSAQ KLKRKVANAA SNSDELKGTK KTAVTLRLGA RSSCSVNRNT
     SSLQLLKCAQ KLQSVLKKDD IVWEP
//