ID G1KG39_ANOCA Unreviewed; 1187 AA.
AC G1KG39;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=WW and C2 domain containing 2 {ECO:0000313|Ensembl:ENSACAP00000006919.3};
GN Name=WWC2 {ECO:0000313|Ensembl:ENSACAP00000006919.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006919.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000006919.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000006919.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000006919.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008110039.1; XM_008111832.2.
DR AlphaFoldDB; G1KG39; -.
DR STRING; 28377.ENSACAP00000006919; -.
DR Ensembl; ENSACAT00000007070.4; ENSACAP00000006919.3; ENSACAG00000006981.4.
DR GeneID; 100560780; -.
DR KEGG; acs:100560780; -.
DR CTD; 80014; -.
DR eggNOG; KOG3209; Eukaryota.
DR GeneTree; ENSGT00410000025556; -.
DR HOGENOM; CLU_005420_0_0_1; -.
DR InParanoid; G1KG39; -.
DR OrthoDB; 1334597at2759; -.
DR TreeFam; TF324040; -.
DR Proteomes; UP000001646; Chromosome 5.
DR Bgee; ENSACAG00000006981; Expressed in hemipenis and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0019900; F:kinase binding; IBA:GO_Central.
DR GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0035331; P:negative regulation of hippo signaling; IEA:Ensembl.
DR GO; GO:0046621; P:negative regulation of organ growth; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0035330; P:regulation of hippo signaling; IBA:GO_Central.
DR CDD; cd08680; C2_Kibra; 1.
DR CDD; cd00201; WW; 2.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037771; C2_WWC.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR14791; BOMB/KIRA PROTEINS; 1.
DR PANTHER; PTHR14791:SF26; PROTEIN WWC2; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00397; WW; 2.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 10..43
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 57..90
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 692..815
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 515..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..886
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 306..419
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 515..529
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..886
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..983
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1187 AA; 133569 MW; E326FE5629EF812E CRC64;
MPRDAGDGQL PLPDGWEEAR DYDGKVFFID HNTKQTSWID PRDRLTKPLS FADCVGDELP
WGWEDAYDPQ IGVYYIDHIN QTTQIEDPRK QWRQEQEKML KDYLTVAQDA LNTQKELYHV
KEQRLALALD EYVRLNDAYK EKSSSRTSLF SSSSSSTKYD PDILKAEIST TRLRVKKLKR
ELSQMKQELL YKEQGYETLQ QIDQKMSGGQ SGYELSEAKA IVNELKSIRK AISSGEKEKQ
DLMQSLVKLR ERFLLDQTIH RSSEPDMKCS QVHSHLSLSR QTLDAGSQTD ISGEVDVRNM
SNLAEKVKLS LQYEDAKRRM ANLKIELSKL DSEAWPGALD IEKEKLMLIN EKEELLKELQ
FVTPCKRSQD ELKHLEMERK RLEEELSVKN TPSDELTERL KLEERRSKLV QKLQETSKET
TNLHLQLKSL SASTLSVSSG SSLGSLASSQ GSLNTSSRGS LNSLSSTDLY YNQVDQPTDL
DYQYKLDFLL QEKCGYIPSG PITTIHENEV VSSHGRMEYS GSSGSLAASH APKLTEPPKS
VTSLSSRSSL SSLSPPGSPL ALEGTFSVPP QDSPLHHLTT DFEDCDLPSD FASISLCGNQ
ILDSEARVSS QSLADDKDLN ESLNQTISPP RNTGVDLPRR VSHLLEEKAG CVSAAVSDES
VAGDSGVYEA SVKQPNDGEE VAYSEDDTTV LETAQVQIGL RYDTTSSSFV IIVVRLQNLH
ALSVSPGSKV YFRVAVLPSS ADISCLFRTK VYSAAETILF SEMFRVSISQ ASLHQKTLRV
DVCSVSKTRR EECLAGTQIS LADLSLSNET STLWYNLLAY KQIHGKKKPK EDPVFVPNSE
SSDSLDLDAV SALLERTSAE LQAVEQELAK EEEEEEEEEE EKDAQDLQNV EEDWLGIHAE
ASNAIVTEEE GAVKNAEEIG DADSSTELVE TEEIKDEEDS SCTHVDPNEE IAALPTLVDK
ETNTDERTES VAVRPKDRTS LKSQQHPFVR NSMIVRSQTF SPGERNQYIC RLNRSDSDSS
TLAKKSLFVR NATERRSLRV KRPACQPSMR RATREHLVRT SLDLELDLQA SRTRQSRLDD
ELQMLRDLKQ RLEEMKARGK TELPPCVLED ERFQKLLKQA EKQAEQSKEE KKRGLSAEKL
MRKASKDVCR LREQSQKVPL QVQSFREKIA YFTRAKISIP SLPADDV
//
