UniProt: G1KH55

Database: UniProt
Entry: G1KH55_ANOCA

LinkDB:  G1KH55_ANOCA 
Original site:  G1KH55_ANOCA

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (3)   
   ENSEMBL-UP (3)   
Protein domain (9)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (2)   
All databases (16)   

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ID   G1KH55_ANOCA            Unreviewed;       375 AA.
AC   G1KH55;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   27-MAR-2024, entry version 80.
DE   RecName: Full=renin {ECO:0000256|ARBA:ARBA00013216};
DE            EC=3.4.23.15 {ECO:0000256|ARBA:ARBA00013216};
DE   AltName: Full=Angiotensinogenase {ECO:0000256|ARBA:ARBA00032220};
GN   Name=REN {ECO:0000313|Ensembl:ENSACAP00000007721.3};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000007721.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000007721.3, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000007721.3,
RC   ECO:0000313|Proteomes:UP000001646};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000007721.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleavage of Leu-|-Xaa bond in angiotensinogen to generate
CC         angiotensin I.; EC=3.4.23.15;
CC         Evidence={ECO:0000256|ARBA:ARBA00000430};
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   AlphaFoldDB; G1KH55; -.
DR   STRING; 28377.ENSACAP00000007721; -.
DR   MEROPS; A01.007; -.
DR   Ensembl; ENSACAT00000007886.4; ENSACAP00000007721.3; ENSACAG00000007697.4.
DR   eggNOG; KOG1339; Eukaryota.
DR   GeneTree; ENSGT00940000157898; -.
DR   HOGENOM; CLU_013253_3_3_1; -.
DR   OrthoDB; 1120702at2759; -.
DR   TreeFam; TF314990; -.
DR   Proteomes; UP000001646; Chromosome 4.
DR   Bgee; ENSACAG00000007697; Expressed in kidney and 3 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0002003; P:angiotensin maturation; IBA:GO_Central.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR012848; Aspartic_peptidase_N.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF24; RENIN; 1.
DR   Pfam; PF07966; A1_Propeptide; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT   DOMAIN          56..372
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        74
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        260
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        87..94
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        251..255
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        294..331
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   375 AA;  41456 MW;  B4BA2F1C2F841C1A CRC64;
     IIPLKKMPSI RETLQKMGIK VADFFPSLKH GIYFLNDGFY NGTAPTILTN YLDMQYYGEI
     SIGTPAQIFK VVFDTGSANL WVPSQQCSPL YSACVSHNRY DSSRSSTYKP NGTEIAIQYG
     QGYVKGFLSQ DIVRVADIPV VQLFAEAIAL PNKPFIYARF DGVLGMGYPS QAIDGVIPVF
     DKIISERVLS EEVFSVYYSR NSEMNTGGEI ILGGSDPSYY TGDFHYVSIS TPGYWHIDLK
     GVSLGSEMLF CHEGCTAAVD TGSSFITGPA SAVSILMKSI GATLLEERDY VVECKKIHLL
     PDISFHLGDR SYTLSGYAYV LQYSDYGKEL CAVAFSAFDI PPPLGPIWIL GATFIGQYYT
     EFDRQNNRIG FARSL
//

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