ID G1KHJ3_ANOCA Unreviewed; 698 AA.
AC G1KHJ3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=VWFD domain-containing protein {ECO:0000259|PROSITE:PS51233};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000008080.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000008080.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000008080.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000008080.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR AlphaFoldDB; G1KHJ3; -.
DR STRING; 28377.ENSACAP00000008080; -.
DR Ensembl; ENSACAT00000008252.3; ENSACAP00000008080.3; ENSACAG00000008239.4.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000164528; -.
DR HOGENOM; CLU_000076_2_1_1; -.
DR InParanoid; G1KHJ3; -.
DR Proteomes; UP000001646; Chromosome 5.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd19941; TIL; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR47246; MUCIN-19; 1.
DR PANTHER; PTHR47246:SF1; MUCIN-19; 1.
DR Pfam; PF08742; C8; 2.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00832; C8; 2.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 2.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 282..447
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
SQ SEQUENCE 698 AA; 78463 MW; E0A38DF808361093 CRC64;
MANIQCQQTN NIYSQTQRHL TFFSRESCFV LFCFVFVFQK CLMSTCLCEE IKDCLCTALG
NYVKACTKHG VYITDWRRGM CEQKCEGGKV FQYNAKACNT SCRSFSERDL SCDVEDSPVD
GCLCPEGLYL NSKGKCVNQD ACDCYMDNKV QAAYICFFLF KFHSVCRKGQ LFCYNSTDLK
PVTCNGGAEF MTCSDPKAKR RIEKTCTSLN MPHLSTDMPC SPGCYCPLDM VRDNEGKCIL
PTSCPCSYSG RKYEQGSLIK ISCNTCTCVQ GTWECETGKC QSSCHIYGDG QIQTFDGKWY
SYDGLCQYRV CIKCVSMHNL VLTESVPCCE DGITCSRKIT DGTLVLEDGK FMFTKDAGST
KCTDKEPYTV HTVGLYLIIR FIGGITLIWD KNTRVSIVMD SDWNKQTCGL CGNHNGKILD
EFTTRGGSLA AGTVEFGNSW KTSPMCSDTV SEIFPCDANA YCKQWAVRKC EIIMEQHFRM
CHNKVDPTPY HKACIEEACV CTMEGKYHGF CTAVSMYAEA CAAVGICISW RTPELCPVFC
DYYNAPGECS WHYKPCGSMA TKTCKQNAGE WDLPSVLEGC YAKCPEHKPY LDENTMKCVR
LSDCTCYHNE IVLPGEFIYD ECGRLWAVVH WSQFISVPFH IGHFAGSAML LSNSRPLLDA
AVAHLHNTLP CKCKFIFELT ATPTGFQPYY FEFFTLLT
//
