ID   G1KIG1_ANOCA            Unreviewed;       343 AA.
AC   G1KIG1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 3.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Citramalyl-CoA lyase {ECO:0000313|Ensembl:ENSACAP00000008895.4};
GN   Name=CLYBL {ECO:0000313|Ensembl:ENSACAP00000008895.4};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000008895.4, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000008895.4, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000008895.4,
RC   ECO:0000313|Proteomes:UP000001646};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000008895.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR   RefSeq; XP_008105166.1; XM_008106959.2.
DR   AlphaFoldDB; G1KIG1; -.
DR   STRING; 28377.ENSACAP00000008895; -.
DR   Ensembl; ENSACAT00000009086.4; ENSACAP00000008895.4; ENSACAG00000009072.4.
DR   GeneID; 100566356; -.
DR   KEGG; acs:100566356; -.
DR   CTD; 171425; -.
DR   eggNOG; ENOG502QQPK; Eukaryota.
DR   GeneTree; ENSGT00390000017163; -.
DR   HOGENOM; CLU_044864_1_1_1; -.
DR   InParanoid; G1KIG1; -.
DR   OrthoDB; 2874421at2759; -.
DR   TreeFam; TF313596; -.
DR   Proteomes; UP000001646; Chromosome 3.
DR   Bgee; ENSACAG00000009072; Expressed in heart and 13 other cell types or tissues.
DR   GO; GO:0047777; F:(S)-citramalyl-CoA lyase activity; IBA:GO_Central.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR   GO; GO:0004474; F:malate synthase activity; IEA:Ensembl.
DR   GO; GO:0106121; P:positive regulation of cobalamin metabolic process; IEA:Ensembl.
DR   GO; GO:0070207; P:protein homotrimerization; IEA:Ensembl.
DR   GO; GO:0106064; P:regulation of cobalamin metabolic process; IBA:GO_Central.
DR   Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR   InterPro; IPR005000; Aldolase/citrate-lyase_domain.
DR   InterPro; IPR040186; Citramalyl-CoA_lyase.
DR   InterPro; IPR011206; Citrate_lyase_beta/mcl1/mcl2.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR   PANTHER; PTHR11105:SF0; CITRAMALYL-COA LYASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11105; CITRATE LYASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF03328; HpcH_HpaI; 1.
DR   PIRSF; PIRSF015582; Cit_lyase_B; 1.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
PE   4: Predicted;
KW   Magnesium {ECO:0000256|PIRSR:PIRSR015582-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR015582-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT   DOMAIN          49..277
FT                   /note="HpcH/HpaI aldolase/citrate lyase"
FT                   /evidence="ECO:0000259|Pfam:PF03328"
FT   BINDING         110
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015582-1"
FT   BINDING         174
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015582-2"
FT   BINDING         174
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015582-1"
FT   BINDING         209
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015582-2"
SQ   SEQUENCE   343 AA;  38014 MW;  EA203CF50D380B78 CRC64;
     MTTTMTGSRR LLVAGSRLGR CGVRSSFLAV LVPKPDSCFL QSRSYIPRRA VLYVPADDDR
     KVQKIASLKV DCAVLDCEDG VALNRKANAR EKSVKALEEF EFGHTEKCVR INSVSSGLAE
     EDLKVILDSS VLPTSLMLPK VESVEEIIWF AEKFASHLKG RTCVKPMNFI PFVETAMGLL
     NFKAVCEETL RKGPQIGLHL DAVVFGGEDF RASIGSTSSK ETLDILYARQ KIVVTAKAFG
     MQAIDLVYID FQDEEGLRKQ SREGALMGFT GKQVIHPNQV AVVQEEFSPS SEKMKWAQEL
     IMAFEEHQRV GKGAFTFRGS MIDMPLLKQA QNIVTLATAI KEK
//