ID G1KIW2_ANOCA Unreviewed; 1936 AA.
AC G1KIW2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Myosin heavy chain 4 {ECO:0008006|Google:ProtNLM};
GN Name=LOC100555977 {ECO:0000313|Ensembl:ENSACAP00000009228.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000009228.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000009228.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000009228.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000009228.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 28377.ENSACAP00000009228; -.
DR Ensembl; ENSACAT00000009421.3; ENSACAP00000009228.3; ENSACAG00000017325.3.
DR eggNOG; KOG0161; Eukaryota.
DR GeneTree; ENSGT00940000161336; -.
DR HOGENOM; CLU_000192_8_1_1; -.
DR TreeFam; TF314375; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000017325; Expressed in skeletal muscle tissue and 2 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0032982; C:myosin filament; IBA:GO_Central.
DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 5.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF44; MYOSIN-13; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..780
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 657..679
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 995..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1846..1908
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1936 AA; 222708 MW; 359258C8563177E0 CRC64;
MTSDAEMAVF GEAAPFLRKP EKERIEAQNR PFDAKISTFV VDEKEMYVKG IIQSREAGKV
TVKTLDDRTV TVKDDEVFPM NPPKFDKIED MVMMTHLHEP AVLYNLKERY ASWMIYTYSG
LFCVTVNPYK WLPVYNPEVV SGYRGKKRQE APPHIFSISD NAYQFMLTDR ENQSVLITGE
SGAGKTVNTK RVIQYFATIA VAGDKKKEAQ PSKMQGTLED QIIQANPLLE AFGNAKTVRN
DNSSRFGKFI RIHFGTTGKL ASADIETYLL EKSRVTFQLS AERSYHIFYQ IMSNKKPELI
DLLLISTNPY DFPFVSQGEL TVASIDDSEE LLATDSAIDI LGFSAEEKVG IYKLTGAVMH
YGNLKFKQKQ REEQAEPDGT EVADKAGYLM GLNSADLLKG LCYPRVKVGN EYVTKGQNVQ
QVYNSVGALA KSVYEKMFLW MVTRINQQLD TKQPRQHFIG VLDIAGFEIF DYNSLEQLCI
NFTNEKLQQF FNHHMFVLEQ EEYKKEGIDW EFIDFGMDLA ACIELIEKPM GIFSILEEEC
MFPKATDTSF KNKLYDQHLG KSNNFQKPKP VKGKAEAHFS LVHYAGTVDY NITGWLDKNK
DPLNESVVAL YQKSSLKLLS FLYSNYAATE AGGGSKKGGK KKGGSFQTVS AVFRENLNKL
MTNLRSTHPH FVRCLIPNET KTPGIMDHHL VMHQLRCNGV LEGIRICRKG FPSRILYADF
KQRYKILNAS AIPEGQFIDS KKASEKLLSS IDVDHNQYRF GHTKVFFKAG LLGLLEEMRD
EKLVALITHT QAMCRGFLMR VEFQKMNARR ESIYVIQYNV RSFMNVKHWP WMKLYFKIKP
LLRSAESEKE MANMKEEFEK TKEDLAKSEA KRKELEEKMV TLVQEKNDLQ LQVQSETESL
ADAEERCEGL IKSKIQLEAK IKELTERLED EEEMNAELTA KKRKLEDECS ELKKDIDDLE
LTLAKVEKEK HATENKVKNL TEEMAALDES ISKLSKEKKS LQEAHQQTLD DLQAEEDKVN
TLSKTKSKLE QQVDDLEGSL EQEKKLRMDL ERAKRKLEGD LKMSQESVMD LENDKQQMDD
KLKKKEFEIG QLQGKIEDEQ AQSSQLQKKI KELQARMEEL EEEIEAERAS RAKAEKQRSD
LSRELEEISE RLEEAGGATS AQIEMNKKRE AEFQKMRRDL EEATLNHEAT TAALRKKHAD
SVAELGEQID NLQRVKQKLE KEKSELKMEI DDLASNMESV SKAKSNLEKM CRTLEDQFNE
IKTKDEEHVR LINDLNAHKA RLNTENGEFS RQLEEKESLI SQLIRGKQAF TQQTEELKRQ
LEEENKAKNA LAHALQSARH DCDLLREQFE EEQEAKGELQ RAMSKANSEV AQWRTKYETD
AIQRTEELEE AKKKLAQRLQ ESEEQTEAVN SKCASLEKTK QRLQGEVDDL MIDVERSNAA
CAALDKRQRN FDKVLAEWKQ KYQECQAELE SSQKESRSLS TEIFKMKNAY EEVLDQLETV
RRENKNLQQE ISDLTEQIAE AGKSSHELEK AKKHVEQERS DLQAALEEAE GSLEHEEGKI
LRVQLELNQL KSEIDRKVAE KDEEIEQLKR NHQRMMDTMQ STLDSEVRSR NDALRIKKKM
EGDLNEMEIQ LSHANRQAAE TQKHLRNVQG QLKDSQLHLD DALRGNEDLK EQLALVERRN
TLMTTELEEM RMALEQTERA RKVCEQELTD ASERVQLLHS QNTSLLNTKK KLETDLAQFQ
GEIDDAIQEA RNAEEKAKKA ITDAAMMAEE LKKEQDTSAH LERMKKNLEQ TVKDLQHRLD
EAEQLALRGG KKQLQKLEAR VCMRRGCQAL CVRAGNDFAE EDKKNVFRLQ DLVDKLQLKV
KAYKRQAEEA EELANSNLSR CRKAQHELEE AEERADIAES QVNKLRAKSR DIGGKVSALE
KPFRSVFSKQ NTAYTE
//
