ID G1KK30_ANOCA Unreviewed; 486 AA.
AC G1KK30;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Zinc finger protein RFP-like {ECO:0008006|Google:ProtNLM};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000010227.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000010227.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000010227.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000010227.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Neurotoxin that produces dose-dependent hypolocomotion and
CC hyperalgesia in mice. May directly act on the central nervous system,
CC as it is 6500-fold more potent when administered
CC intracerebroventricularly than intraperitoneal.
CC {ECO:0000256|ARBA:ARBA00034460}.
CC -!- SIMILARITY: Belongs to the ohanin/vespryn family.
CC {ECO:0000256|ARBA:ARBA00009651}.
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DR AlphaFoldDB; G1KK30; -.
DR Ensembl; ENSACAT00000010438.4; ENSACAP00000010227.3; ENSACAG00000010478.4.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT01030000234669; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR TreeFam; TF338674; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000010478; Expressed in adrenal gland and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR CDD; cd16594; RING-HC_TRIM7-like_C-IV; 1.
DR CDD; cd12888; SPRY_PRY_TRIM7_like; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24103:SF691; B30.2_SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24103; E3 UBIQUITIN-PROTEIN LIGASE TRIM; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Neurotoxin {ECO:0000256|ARBA:ARBA00022699};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Toxin {ECO:0000256|ARBA:ARBA00022699};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 20..62
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 96..135
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 297..486
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT COILED 164..242
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 486 AA; 55848 MW; 692E7C5B41D8F413 CRC64;
MAAAPRAQDP LQDLCEEATC LICLDYLKDP VSLECGHNFC RACLTQTWKK SGNIETSCSH
CREPVSEKNL RTNQQLANLV EKVKILSSQG SKKTQGKEGV CEKHQEPLKF FCKDDETPIC
EMCDREHRDH RRIPLGTAAQ DYKLLMRLRQ DDLVKKREKI LVYKTETEKE AQELLKQAKT
KMETTLEEIP EIQQFLDKQE QHPRSQMEEL QKQIAQKRDE HLVLLSRELS SLEGFIQELK
EKCQQPPAEL LRDVRNLLQR CEEKQTSEKP MAFPPELKWK VWEFCDLNSY LVAAMKPFRA
AFLDALLPGL ELQKANVTLD PNTAGTWLIL SEDQKSVRFG DEPQDLLDNP ERFSDRAYVL
GQEGFTSGRH FWDVVVGEEG DWAVGVARES VRRKGLVNID PEEGIWVVSK WRGKYHATSW
PSSTDFLLSE KTKRVRVCLN YAANQVAFYD ADTGDQICLL SEIPFSGETA LPFFHVHKKG
HLRISP
//
