ID G1KKZ6_ANOCA Unreviewed; 225 AA.
AC G1KKZ6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Metalloproteinase inhibitor 1 {ECO:0000256|ARBA:ARBA00013524};
DE AltName: Full=Tissue inhibitor of metalloproteinases 1 {ECO:0000256|ARBA:ARBA00030100};
GN Name=LOC100551718 {ECO:0000313|Ensembl:ENSACAP00000010993.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000010993.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000010993.4, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000010993.4,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000010993.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protease inhibitor I35 (TIMP) family.
CC {ECO:0000256|ARBA:ARBA00011027}.
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DR AlphaFoldDB; G1KKZ6; -.
DR STRING; 28377.ENSACAP00000010993; -.
DR Ensembl; ENSACAT00000011221.4; ENSACAP00000010993.4; ENSACAG00000041669.1.
DR eggNOG; KOG4745; Eukaryota.
DR GeneTree; ENSGT00940000161081; -.
DR HOGENOM; CLU_084029_0_0_1; -.
DR OrthoDB; 5403389at2759; -.
DR TreeFam; TF317409; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000011200; Expressed in liver and 10 other cell types or tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0002020; F:protease binding; IBA:GO_Central.
DR GO; GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; IBA:GO_Central.
DR GO; GO:0034097; P:response to cytokine; IBA:GO_Central.
DR GO; GO:0009725; P:response to hormone; IBA:GO_Central.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 3.90.370.10; Tissue inhibitor of metalloproteinase-1. Chain B, domain 1; 1.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR001820; TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR InterPro; IPR027465; TIMP_C.
DR PANTHER; PTHR11844; METALLOPROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11844:SF20; METALLOPROTEINASE INHIBITOR 1; 1.
DR Pfam; PF00965; TIMP; 1.
DR SMART; SM00206; NTR; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR601820-3};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601820-1};
KW Metalloenzyme inhibitor {ECO:0000256|ARBA:ARBA00023215};
KW Metalloprotease inhibitor {ECO:0000256|ARBA:ARBA00022608};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|PIRSR:PIRSR601820-1}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..225
FT /note="Metalloproteinase inhibitor 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5033018342"
FT DOMAIN 33..155
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT BINDING 33
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared with metalloproteinase partner"
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-1"
FT DISULFID 33..102
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 35..130
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 45..155
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 157..205
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 162..166
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
FT DISULFID 174..195
FT /evidence="ECO:0000256|PIRSR:PIRSR601820-3"
SQ SEQUENCE 225 AA; 25539 MW; D393D530A11ACBAC CRC64;
MTERRKMNLA KVSGFLSASF LLLTLLGDTT EACSCARRHP QTAFCSSDIV LRAKFVAVNK
MEGNLSERRW MYHEIKTIKL YKGPEEMQDV RYVHTPPIDG ACGYFHGGPL KEEYLITGRV
KGGRVTISIC NFIRPWAEIT LAQKRGFTSE YSKGCSCSIV SCHSECSITS DNQCLWTDLL
RSQNQSYFQD KHLACLPRAE KNGMCTWKSL GTQRSGSFRK RRLTQ
//
