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Database: UniProt
Entry: G1KLX9_ANOCA
LinkDB: G1KLX9_ANOCA
Original site: G1KLX9_ANOCA 
ID   G1KLX9_ANOCA            Unreviewed;      2701 AA.
AC   G1KLX9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   16-JAN-2019, entry version 50.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 2 {ECO:0000313|Ensembl:ENSACAP00000011934};
GN   Name=ITPR2 {ECO:0000313|Ensembl:ENSACAP00000011934};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000011934, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000011934, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000011934};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000011934}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   RefSeq; XP_003221537.1; XM_003221489.3.
DR   STRING; 28377.ENSACAP00000011934; -.
DR   Ensembl; ENSACAT00000012178; ENSACAP00000011934; ENSACAG00000011690.
DR   GeneID; 100567982; -.
DR   KEGG; acs:100567982; -.
DR   CTD; 3709; -.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00940000156039; -.
DR   InParanoid; G1KLX9; -.
DR   KO; K04959; -.
DR   OrthoDB; 94996at2759; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000001646; Chromosome 5.
DR   Bgee; ENSACAG00000011690; Expressed in 4 organ(s), highest expression level in brain.
DR   GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0030667; C:secretory granule membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IBA:GO_Central.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:0071361; P:cellular response to ethanol; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2229   2251       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2263   2282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2303   2327       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2347   2375       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2396   2418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2522   2545       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      112    166       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      173    223       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      231    287       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      294    358       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      379    435       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       89    109       {ECO:0000256|SAM:Coils}.
FT   COILED     1598   1618       {ECO:0000256|SAM:Coils}.
FT   COILED     1924   1944       {ECO:0000256|SAM:Coils}.
FT   COILED     2632   2680       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2701 AA;  308318 MW;  D59BA734868EC964 CRC64;
     MSDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVQ PEAGDLCNPP KKFRDCLFKV
     CPMNRYSAQK QYWKAKQAKQ GNHTEAALLK KLQHAAELEQ KQNESENKKL LGEIVKYSNV
     IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDAAGNEGSW FYIQPFWKLR SEGDNIVVGD
     KVVLMPVNAG QPLHASNIEL LDNPGCKEVN AVNCNTSWKI TLFMKFSCYR EDVLKGGDVV
     RLFHAEQEKF LTCDEYQKKQ HIFLRTTLRQ SATSATSSKA LWEIEVVHHD PCRGGAGQWN
     SLFRFKHLAT GNYLAAELNP HYPDGSIGER SVQRDDELLT SKKKRQAGEK IMFTLVSVPH
     GNDIASLFEL DATTLQRADC LVPRNSYVRL RHLCTNTWVT SSSIPIDKDE ERPVMLKIGT
     CQTKEDKEAF AIVSVPLSEV RDLDFANDAN KVLASTVKKL ENGSVTQNER RFVTKLLEDL
     IFFVADVHNN GQEVLDVVVI KANRERQKLM REQNILAQIF GILKAPFKDK VGEGAMLRLE
     DLGDQRYAPY KYMLRLCYRI LRHSQQDYRK NQEYIAKNFC VMQSQIGYDI LAEDTITALL
     HNNRKLLEKH ITAKEIETFV NLLRRNREPR FLDYLSDLCV SNTTAIPVTQ ELICKYMLSP
     GNADILIQTK LVSMQMENPL ECSVLSDDMD DEEVWLYWID SNKEPHGKAI RHLAQEAKEG
     TKTDLEVLTY YRYQLNLFAR MCLDRQYLAI NQISTQLSVD LILRCMSDES LPYDLRASFC
     RLMLHMHVDR DPQETVVPVK YARLWTEIPT KITIHEYDSF TDSSRNDMKR KFALTMECVE
     EYLKEVVNQP FPFGDKEKNK LTFEVVHLAR NLIYFGFYSF SELLRLTRTL LAILDIVQVP
     MSSYLERLSK FQDGGNNVMR TIHGVGEMMT QMVLSRGSIF PISVPDIPPS THPSKQANIV
     ESEDVTVMDT KLKIIEILQF ILSVRLDYRI SYMLSIYKKE FGENNENTDS TIMSQADSPV
     ITSAVVPDID EIAAQAETMF AGRKEKNAVQ LDDEGGRTFL RVLIHLIMHD YPPLLSGALH
     LLFKHFSQRA EVLQAFKQVQ LLVSNQDVDN YKQIKADLDQ LRLTVEKSEL WVEKSSSYES
     GELGESQTKG SDEPNEESNM LSPVQDGSKK PQIDSNKSNN YNIVMEILNR LSKLCVQNKK
     CRNQQQRLLK NMGAHSVVLD LLQIPYEKTD EKMNEIMNLA HLFLQNFCRG NPQNQVLLHK
     HLTLFLTPGL LEAETMRHIF TNNYLLCNEI SERVVQHFVH SIETHGRHVE YLRFLQTIVK
     ADGKYVKKCQ DMVMTELANG GEDVLVFYND RASFPILLQM MCSERERVDE SGSLAYHITL
     VELLAACTEG KNVYTEIKCN SLLPLDDIVR VVTHDDCIPE VKIAYVNFVN HCYVDTEVEM
     KEIYTSNHIW KLFENFLVDM ARVCNTTTDR KHADVSLEKY VTEPVMNIIS GFFNSPFSDN
     STSLQTHQPV FIQLLQSAFR IYNCTWPNPA QKSSVESCIK TLAEVAKNRG IAIPVDLDSQ
     VNTLFMKSHS NMVQRAAMGW RMTARSGPRF KEPLGGPAWD YRNIIEKLQD VVASLEQQFS
     PMMQAEFSVL VDVLHSPELL FPEGSDARIR CGAFMSKLIN HTKRLMEKEE KLCIKILQTL
     REMLEKKDSF VEEGSNLRKI LLNRYFKGDY GSSVNGPLSS NFSKASHVGA SFSGQDFDKS
     GVSMHDIQCL LDKEGASELV TDVIVSTKND RIFSEAILLG IALLEGGNTQ IQYSFFQQLN
     EQKKSEKFFK VLYDRVKTAQ QEIRSTVTVN TIDLSSKKKE EDNDITISVP KKRVRDSNLH
     LKEGMKGQLT EASTATSKAY CVYRREMDPE IDLMSAGTDS GNAEEKSSEE VTMSPAIVIM
     QPILRFLQLL CENHNRELQN FLRNQNNKTN YNLVCETLQF LDCICGSTTG GLGLLGLYIN
     EKNVALVNQT LESLTEYCQG PCHENQTCIA THESNGIDII IALILNDINP LGKYRMDLVL
     QLKNNASKLL LAIMESRHDS ENAERILFNM RPRELVDVMK NAYNQGLESD HEEESGDDSI
     SPKDVGHNIY ILAHQLARHN KVLQHMLKPG SDPEEGDEAL KHYAKHTAQI EIVRYDRTME
     QIVFPVPNIC EFLTHESKYR VFNTTERDEQ GSKVNDFFQQ AEDLYNEMKW QKKIRNNPAL
     FWFSRHISLW GSISFNLAVF INLAVALFYP FGDDGDEGTL SPLFSVLLWI AVGICTSLLF
     FFPKPVGIRP FLVSVMLRSI YTIGLGPTLI LLGAANLCNK IVFLVSFVGN RGTFTRGYRA
     VIMDMAFLYH VVYVLVCMLG LCVHEFFYSF LLFDLVYREE TLLNVIKSVT RNGRSIILTA
     VLALILVYLF SIVGFLFLKD DFIMEVERLK NRTPIADGDT FSTTSLTTMD TCSKENCTTT
     IPALQSDEEA DEDGIERTCD TLLMCIVTVL NQGLRNGGGV GDVLRKPSKD EPLFAARVVY
     DLLFYFIVII IVLNLIFGVI IDTFADLRSE KQKKEEILKT TCFICGLERD KFDNKTVSFE
     EHIKSEHNMW HYLYFIVLVR VKDPTEYTGP ESYVAQMIQE KNLDWFPRMR AMSLVSNEGD
     NEQNEIRNLQ ERLESTMSLV KQLSGQLAEL KEQMTEQRKN KQRLGFLGSN APHVNHHMPP
     H
//
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