ID G1KM11_ANOCA Unreviewed; 1171 AA.
AC G1KM11;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Diaphanous related formin 1 {ECO:0000313|Ensembl:ENSACAP00000012009.4};
GN Name=DIAPH1 {ECO:0000313|Ensembl:ENSACAP00000012009.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000012009.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000012009.4, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000012009.4,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000012009.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous
CC subfamily. {ECO:0000256|ARBA:ARBA00008214}.
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DR AlphaFoldDB; G1KM11; -.
DR STRING; 28377.ENSACAP00000012009; -.
DR Ensembl; ENSACAT00000012254.4; ENSACAP00000012009.4; ENSACAG00000011971.4.
DR eggNOG; KOG1924; Eukaryota.
DR GeneTree; ENSGT00940000159910; -.
DR HOGENOM; CLU_002356_0_1_1; -.
DR TreeFam; TF315383; -.
DR Proteomes; UP000001646; Chromosome 4.
DR Bgee; ENSACAG00000011971; Expressed in embryonic post-anal tail and 13 other cell types or tissues.
DR GO; GO:0005884; C:actin filament; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0030041; P:actin filament polymerization; IBA:GO_Central.
DR Gene3D; 1.20.58.630; -; 1.
DR Gene3D; 6.10.30.30; -; 1.
DR Gene3D; 1.10.20.40; Formin, diaphanous GTPase-binding domain; 1.
DR Gene3D; 1.20.58.2220; Formin, FH2 domain; 1.
DR Gene3D; 1.10.238.150; Formin, FH3 diaphanous domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014767; DAD_dom.
DR InterPro; IPR044933; DIA_GBD_sf.
DR InterPro; IPR015425; FH2_Formin.
DR InterPro; IPR042201; FH2_Formin_sf.
DR InterPro; IPR010472; FH3_dom.
DR InterPro; IPR014768; GBD/FH3_dom.
DR InterPro; IPR010473; GTPase-bd.
DR PANTHER; PTHR45691; PROTEIN DIAPHANOUS; 1.
DR PANTHER; PTHR45691:SF4; PROTEIN DIAPHANOUS HOMOLOG 1; 1.
DR Pfam; PF06346; Drf_FH1; 1.
DR Pfam; PF06367; Drf_FH3; 1.
DR Pfam; PF06371; Drf_GBD; 1.
DR Pfam; PF02181; FH2; 1.
DR SMART; SM01139; Drf_FH3; 1.
DR SMART; SM01140; Drf_GBD; 1.
DR SMART; SM00498; FH2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF101447; Formin homology 2 domain (FH2 domain); 1.
DR PROSITE; PS51231; DAD; 1.
DR PROSITE; PS51444; FH2; 1.
DR PROSITE; PS51232; GBD_FH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 39..407
FT /note="GBD/FH3"
FT /evidence="ECO:0000259|PROSITE:PS51232"
FT DOMAIN 698..1102
FT /note="FH2"
FT /evidence="ECO:0000259|PROSITE:PS51444"
FT DOMAIN 1125..1153
FT /note="DAD"
FT /evidence="ECO:0000259|PROSITE:PS51231"
FT REGION 521..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 971..998
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1079..1123
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 534..672
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1171 AA; 131439 MW; FEFEA874A8CFE33F CRC64;
FLPVLERFTS MRIKKEKEKS NAAHRNSSAS YSDVSGQLLQ EISDEDVLVL FEQMLVDMNL
NEEKQQPLRE KDIVIKREMV SQYLHTSKAG MSQKESSKSP MMNIQELKSG LRDAQLLNCL
ESLRVSLNNN PVSWVQNFGA EGLNCLLDIL KGLHDEKDDI LGPYDTRIKH EIIRCLKAFM
NNKFGIKTML ETEDGILLLA RSVDPKVPAM MIDAIKLLSA LCILPQPVDM HEQVLGALTE
RAEMDEVERF KPILDGLKSG TSVALKVVCL QLINALIIPA DELDFRVHIR SELMRSGLQQ
ILKELRTLDN EELLVQLQVF EESGEEDSAD LRSRLEDVRI EIEYPFSAIE VFQILLNTVK
DSKAEQHFLS MLQHLLLVRN DYEARPQYFK LIDECISQIV LHKNGADPDF RRKHLDLHIE
GLIDNLIDQT KVAKSEAKAI ELEKKLDSEL TARHELQVEM KKKENDLEQK LQDLLHEKET
LESEKEQVSL EKKSLENTTS LLNDQIASLM QELEDLKKKM EHITSSSVSP GGAEVSPTPP
PPPPPPPLPG GAAVPPPPPP PPPPPLPGAV AVPPPPPLPG AAAVPPPPPL PGAAGIPPPP
PPPPPLPGMA GVPPPPPPLP GMPGIPPPPP PLPGMTGGPP PPPPLPGMAG MPPPPPPLPG
MAGVPPPPPP LGVPPPPMPP AFGSMTTAAP ALPFGLTPKK LYKPEVQLRR TNWSKVELSE
DCFWAKAKED RFENDELFAK LTLAFSSAQA KCKWLKKQQE NEEEKGQAKK KVKELRVLDS
KNAQNLSIFL GSFRMPYEEI KNAILEVNEV VLTESMVQNL IKLMPEPDKL KMIAELKGDY
AELPEPEQFG VVISSVSRLM PRLRAILFKL QFSEQVENIK PQIVSVTAAC EEVRKSENFS
NLLSIILLVG NYMNSGSMNA GAFGFNISFL CKLRDTKSAD QKLTLLHFLV ETCEQQYPDV
LKFPDELIHV EKACQVSAEN LRKNLDQMKK QISDVQRDVD SFPSATEEKD KFVEKMTISF
KIHFVKEAQE QYEKLRMMHS NMENLYKELG QYFLFNTNKV SIEDFFTDLH NFRNMFVQAL
KENQKRRETE EKMRRAKLAK EKAEKERQEK QQKREQLIDM NAEGDETGVM DSLMEALQSG
AAFRRKRGPR QGKVLFTCFK NSGQPFHCRS W
//
