ID G1KM65_ANOCA Unreviewed; 793 AA.
AC G1KM65;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000012106.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000012106.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000012106.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000012106.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1KM65; -.
DR Ensembl; ENSACAT00000012351.3; ENSACAP00000012106.3; ENSACAG00000012353.3.
DR eggNOG; KOG3594; Eukaryota.
DR GeneTree; ENSGT00940000156683; -.
DR HOGENOM; CLU_006480_3_0_1; -.
DR InParanoid; G1KM65; -.
DR TreeFam; TF332299; -.
DR Proteomes; UP000001646; Chromosome 4.
DR Bgee; ENSACAG00000012353; Expressed in forelimb bud and 7 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR032455; Cadherin_C.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF342; PROTOCADHERIN GAMMA-B1; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR Pfam; PF16492; Cadherin_C_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..793
FT /note="Cadherin domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5032701187"
FT TRANSMEM 681..704
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..125
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 126..234
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 235..339
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 340..444
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 445..554
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 570..668
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 793 AA; 87851 MW; 98E4452A75BE548E CRC64;
LQEKKTKLLI LLSLFRGIVL EEVHYFIPEE MAKGSLVGNL AKDLGLNARE LRNRNLHILS
EGKKQYFTIN AENGNLYVND RIDREGICGE STNCHIDFEA VVENPLNVFH ISVAVQDIND
NSPQFLRGNI RLEIIESTLQ GTRFPIGKAE DPDIGKNSLQ NYELSSNQFF ILEVKDSHDQ
NKYAELVLQK PLDHESEQVL HLILTAMDGG EPRKTGTAQI GINITDANDN PPIFTQDVYT
VSLVENSPVG SSILQVVAFD SDEGSNAHIS YTFSSIPERA TQKFNLDPQT GVITIKETIN
FEEIEKYTMS VEAKDGGGLV AHCKIEMKIQ DVNDNAPEVV LASLSSHIPE DAVPGTMIAL
VNVKDRDSGE NGEVVCSLLG DWPFKIVTTS RNYYKLITDG SLDRERKPEY NITIIATDKG
TPPLSSNKTI YLQISDINDN SPAFEEKAYN IFVPENNPSG ASIFTIKASD PDLGHNAQIT
YSIFNSKIED LPLSSFVSIN SETGTIYAQR SFDYEQFRQF QIQVKAQDGG SPPLGSNTTV
SILILDENDN SPRVLYPLPP ADGSALFEVV PHSAEPGYLV TKVIVAVDAD SGHNAWLSYH
LVQATEPALF SIGSHTGEIR TARAFMEKDA VKQRLVVVVK DNGQPSLSAT VTLNLVFAEN
FQEALPEMKN QSRDIETQDD LQFYLVLALA VISFLFLLTV ILAITMKVRK SGNPQFLQCF
GPVPHSKAGA IFPPNFEDGT LPYSYQLCLS SESQRNEFTF LAPKLSLADI FFVVTNLKVV
EEIFIPQMEL SKK
//
