ID G1KMD0_ANOCA Unreviewed; 2020 AA.
AC G1KMD0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Shroom family member 3 {ECO:0000313|Ensembl:ENSACAP00000012234.4};
GN Name=SHROOM3 {ECO:0000313|Ensembl:ENSACAP00000012234.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000012234.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000012234.4, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000012234.4,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000012234.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the shroom family.
CC {ECO:0000256|ARBA:ARBA00006469}.
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DR STRING; 28377.ENSACAP00000012234; -.
DR Ensembl; ENSACAT00000012484.4; ENSACAP00000012234.4; ENSACAG00000012483.4.
DR eggNOG; ENOG502QUU2; Eukaryota.
DR GeneTree; ENSGT00940000157778; -.
DR HOGENOM; CLU_002434_1_0_1; -.
DR TreeFam; TF333370; -.
DR Proteomes; UP000001646; Chromosome 5.
DR Bgee; ENSACAG00000012483; Expressed in hemipenis and 9 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0043296; C:apical junction complex; IBA:GO_Central.
DR GO; GO:0016324; C:apical plasma membrane; IBA:GO_Central.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR Gene3D; 6.10.250.3120; -; 1.
DR InterPro; IPR014800; ASD1_dom.
DR InterPro; IPR014799; ASD2_dom.
DR InterPro; IPR027685; Shroom_fam.
DR PANTHER; PTHR15012; APICAL PROTEIN/SHROOM-RELATED; 1.
DR PANTHER; PTHR15012:SF33; PROTEIN SHROOM3; 1.
DR Pfam; PF08688; ASD1; 1.
DR Pfam; PF08687; ASD2; 1.
DR PROSITE; PS51306; ASD1; 1.
DR PROSITE; PS51307; ASD2; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00637};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 928..1035
FT /note="ASD1"
FT /evidence="ECO:0000259|PROSITE:PS51306"
FT DOMAIN 1697..1991
FT /note="ASD2"
FT /evidence="ECO:0000259|PROSITE:PS51307"
FT REGION 176..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 546..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1119..1144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1328..1700
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1730..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1995..2020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1814..1841
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1889..1916
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 320..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..636
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1029
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1230..1255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1380..1404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1423..1443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1549..1565
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1602..1624
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1633..1685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1686..1700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2001..2020
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2020 AA; 224746 MW; E2C8FFC751E968BA CRC64;
MLIIAECACC NTLSARTASA FVKARSTEGT TWVPSPLCAG RSSQAEFPSL SYITDVKTAR
DWQFGHLGKL AMPSNLRCVF KFLACWTSKP RDTLATKDRT DITASHSLNS ERLRSDLQYD
KAGGVKLRLK NRRSDPVGRP HSWHSAKFIE NQPDLSMMQI SQGMIGSPWH QAYHSSSSTS
DLSSYDHGYL RRSPDQYSSR GSMESLDHTP AGYAQHPCHL SPAKSTNSID QLAHLHSKRD
SAYSSFSTNS SIPEYAAPAF CKERSYSMEN VHSRGRPQEG GMRQADIRYI KTVYNAQRGV
SEEYEVKSSA LQPSYEAQAK GYSSNRFHGS HKGPQTRSSS DSESLCMKAP PLPPTRSDSY
AAIRHHERPS SWSSHEHRKS CRTHPKGAWS HLGQGTPPPG HLQKSAFLEG QLHTVMEKSP
ESSPTVKPKQ VYSQAAQPGQ PLLPTGVYPV PSPEPHFAQV PHPSANHSGM LYPALAKESG
YAPPPAPSPA SYEKAAPCRP HSGLDENGNQ SIPNKAAIFY QPEYVPPVSG KKKEVGDTAT
KFALYRSHPQ AYATSPRQDE SEPSHKAASV IQENMRNAQL SNHSPQPWLS QPRYVNDGNH
SFQSQDCGSE EQLEDKDPNL QRDFTTQNQW SSGKTKQYGF SSLQNIPEST KLQNNMELKE
VRPGKSYAGA KWHYINYSGQ EEKENQGHIP EYWQDQEWQG LEATWDATEH LHGVEPKYEE
PSSLPPKSSD FGIRRLSSSS TQSIQNSQYG RMEPRKVRCS VLEKVSKIEQ REQGTQRPQN
LSSNCFGQNY VSNKPSLNAV EEIQNRHNSQ EHGQFLDEHN RVISVNSSGQ NPYMHHPNER
GTGKAERANW HSSEQQMAAT TTVLAVSPEQ NIYHGGPSEN QSGHLQRSRS TFQLVEEPER
EIVWKVNVQD VNNSQLDIPF NRAYRNSIKD AQSKVLRATS FRRKDLNINP PVGKEPKRRV
QRPASAHLGM RSSAASPHTP KERHSITPTE TKMDYTNKES LPGPLHVPRI GSRKRLTAEQ
KKRSYSEPEK MNEVGVSDSE LSPFSLQKQV LQFVFPENTV ADRRKIFERE NKACSTINLS
KPELKQLQQN ALADYIERKT GKRPSSASQD ISLPYEGSQV PYFQTSGQDG QSLSSSSSMN
SLQDQNLYHH RESLDRVSRT GRGIVTLPPG LTGCFDLHEF DKKKKTSHRN SSGSKSSFPN
WLKADRHHEH RANLELSKGT QTDLDICDQP CPDHQPREKK AHSKKPGKSA SAEDLLDRSE
NQAVAVHVRS RSSPSADKKC QDLLMAENPD FSRFVKDPFY VVGAGTRLFG SKERSQMEKS
AFTHYHPHLH RGSAGVNSPS ALNESQKVLE PPRHLGRTSA FSTPSTETKG RRSDSKQGTR
HIGLSRSGWS SPNVTNSMSS PTDFQVAAEG IVPKRQSRSG KDNHSKVQAQ ILENTTSTPE
ESTEEASWRW KGSVSQRHPP PKLKWLKESG VSRSSVSPQT PGQKVFPRWQ SFPSQSSSCS
DPETPSSQGR LSLHISESCL QISPPPFPQE ESDDDVFLKE GQPCATGPAL ESPPHPLPPP
VPEGSPSTIA GDMEEFPPPP AAILEADEPV AQNSTNLGEE ESAARNLKRF PKSVSEKEKE
PNTAATKSGH PAPLPPITSS GSKTNGATPS LEARQPQNPA SQDSVDNAPL NPPPESENEG
TESYTGKMKS PEDIKDEALA KEIIHKDKSL ASILDPDSKM KTTMDLMEGI FPSGDRLVKE
NKKRKAMQKR PNSPTSSSVP DDNRKDEPAV KEPAMTLVPC PAYYNMSGPK AELLNKIKDM
PDEVSEDDKE VDINEKKAEL IESLSHKMET LKDAKESLLA DIKLNNALGE EVEVLVSGLC
KPNEFEKYKM FIGDLDKLVS LLLSLSGRLA RVENVLSSLS EDADNQERNS LNEKRKMLAG
QHEDACELKE NLDRRERVVL DILCNYLSEE QLRDYQHFVK MKSALLIEQR ELDDKIKLGQ
EQLKCLRESL PSDFILPSKK ASEPSETSSS HRPPPPTSSL
//
