ID G1KPR7_ANOCA Unreviewed; 292 AA.
AC G1KPR7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyldiphosphate specific] {ECO:0000256|ARBA:ARBA00012596};
DE EC=2.5.1.87 {ECO:0000256|ARBA:ARBA00012596};
GN Name=NUS1 {ECO:0000313|Ensembl:ENSACAP00000014053.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000014053.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000014053.2, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000014053.2,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000014053.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate = di-
CC trans,poly-cis-polyprenyl diphosphate + n diphosphate;
CC Xref=Rhea:RHEA:53008, Rhea:RHEA-COMP:13431, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:128769, ChEBI:CHEBI:136960, ChEBI:CHEBI:175763;
CC EC=2.5.1.87; Evidence={ECO:0000256|ARBA:ARBA00000976};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922}.
CC -!- SIMILARITY: Belongs to the UPP synthase family.
CC {ECO:0000256|ARBA:ARBA00005432}.
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DR RefSeq; XP_008118566.1; XM_008120359.2.
DR AlphaFoldDB; G1KPR7; -.
DR STRING; 28377.ENSACAP00000014053; -.
DR Ensembl; ENSACAT00000014340.4; ENSACAP00000014053.2; ENSACAG00000014322.4.
DR GeneID; 100553689; -.
DR KEGG; acs:100553689; -.
DR CTD; 116150; -.
DR eggNOG; KOG2818; Eukaryota.
DR GeneTree; ENSGT00390000003223; -.
DR HOGENOM; CLU_051870_2_1_1; -.
DR InParanoid; G1KPR7; -.
DR OMA; AWSSCAG; -.
DR OrthoDB; 444436at2759; -.
DR TreeFam; TF332448; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000001646; Chromosome 1.
DR Bgee; ENSACAG00000014322; Expressed in kidney and 14 other cell types or tissues.
DR GO; GO:1904423; C:dehydrodolichyl diphosphate synthase complex; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0045547; F:dehydrodolichyl diphosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0042632; P:cholesterol homeostasis; IEA:Ensembl.
DR GO; GO:0019408; P:dolichol biosynthetic process; IBA:GO_Central.
DR GO; GO:0006489; P:dolichyl diphosphate biosynthetic process; IEA:Ensembl.
DR GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Ensembl.
DR GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR GO; GO:0035268; P:protein mannosylation; IEA:Ensembl.
DR GO; GO:0032383; P:regulation of intracellular cholesterol transport; IEA:Ensembl.
DR GO; GO:0038084; P:vascular endothelial growth factor signaling pathway; IEA:Ensembl.
DR Gene3D; 3.40.1180.10; Decaprenyl diphosphate synthase-like; 1.
DR InterPro; IPR038887; Nus1/NgBR.
DR InterPro; IPR001441; UPP_synth-like.
DR InterPro; IPR036424; UPP_synth-like_sf.
DR PANTHER; PTHR21528:SF0; DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT NUS1; 1.
DR PANTHER; PTHR21528; UNCHARACTERIZED; 1.
DR Pfam; PF01255; Prenyltransf; 1.
DR SUPFAM; SSF64005; Undecaprenyl diphosphate synthase; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
SQ SEQUENCE 292 AA; 32215 MW; 722435F83B5B9D26 CRC64;
MSAAYELLWR LLHVLLSLQR ALAAWLRACF FRGRRGRWRW RAASAFSRAL LAPAAAAVAN
GPFAFRRPGA AGRKAAAAAA LGGAGARARK DAKSLQKLPG HVGLVVAEEE QSYADVAGLV
VWCMAVGISY VSVYDHDGIF KRNNSKLMDE ILKQQQELLN LDCSKYPVKF ANQDETDQVL
KCQSTLNVLS SEDGKTDIVR AAQKFCHLVA QKQKKCTDLD MNVLENLLSS TNGFPDPDLI
LKFGPVDSVL GFLPWQIRLT EIVSLPSHVN VSYEEFFSAL CHYADCDQRV GK
//