ID   G1KPS2_ANOCA            Unreviewed;       781 AA.
AC   G1KPS2;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=Protein phosphatase 1 regulatory subunit 21 {ECO:0000256|ARBA:ARBA00020102};
DE   AltName: Full=Coiled-coil domain-containing protein 128 {ECO:0000256|ARBA:ARBA00031617};
DE   AltName: Full=KLRAQ motif-containing protein 1 {ECO:0000256|ARBA:ARBA00031361};
GN   Name=PPP1R21 {ECO:0000313|Ensembl:ENSACAP00000014060.2};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000014060.2, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000014060.2, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000014060.2,
RC   ECO:0000313|Proteomes:UP000001646};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000014060.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC       Endosome {ECO:0000256|ARBA:ARBA00004177}.
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DR   RefSeq; XP_003216166.1; XM_003216118.3.
DR   AlphaFoldDB; G1KPS2; -.
DR   STRING; 28377.ENSACAP00000014060; -.
DR   Ensembl; ENSACAT00000014347.4; ENSACAP00000014060.2; ENSACAG00000014250.4.
DR   GeneID; 100561019; -.
DR   KEGG; acs:100561019; -.
DR   CTD; 129285; -.
DR   eggNOG; KOG4421; Eukaryota.
DR   GeneTree; ENSGT00390000006820; -.
DR   HOGENOM; CLU_022372_0_0_1; -.
DR   OMA; NLHTYTE; -.
DR   OrthoDB; 2882462at2759; -.
DR   TreeFam; TF320535; -.
DR   Proteomes; UP000001646; Chromosome 1.
DR   Bgee; ENSACAG00000014250; Expressed in hindlimb bud and 13 other cell types or tissues.
DR   GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR   InterPro; IPR040024; PPP1R21.
DR   InterPro; IPR049372; PPP1R21_C.
DR   InterPro; IPR019343; PPP1R21_N.
DR   InterPro; IPR019348; PPP1R21_six_helix.
DR   PANTHER; PTHR21448:SF0; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 21; 1.
DR   PANTHER; PTHR21448; SMOOTH MUSCLE MYOSIN HEAVY CHAIN-RELATED; 1.
DR   Pfam; PF10205; KLRAQ; 1.
DR   Pfam; PF21636; PPP1R21_C; 1.
DR   Pfam; PF10212; PPP1R21_helical; 1.
DR   SMART; SM01254; KLRAQ; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT   DOMAIN          12..113
FT                   /note="Protein phosphatase 1 regulatory subunit 21 N-
FT                   terminal"
FT                   /evidence="ECO:0000259|SMART:SM01254"
FT   REGION          86..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          145..204
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          559..593
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          711..738
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   781 AA;  89285 MW;  43066216C578526E CRC64;
     MAAAAELQGK YQKLAQEYSK LRAQNHVLKK GVVDEQANSA ALKEQLKMKD QSLRKLQQEM
     DSLTFRNQQL AKRVELLQDE LVLSESKGRK NKKSGEPTSQ LSQEQKNVFD EDLQKKIEEN
     ERLHIQFFEA DEQHKRLEID LRNRLEVLEM EAAQHQAVVD GLTRKYMDTI EKLQSDKAKL
     EIKSQTLERE AKDCRVRMEE CQQQLKHLHS DLSSRLDDSL HIIREKLPFN DTKSIKHNAL
     NVPFHNRWRQ LKLRDLAGQA VTFVQDLVTA LLNFHTYTEQ RVQIFPIDSA TDTISPLNQK
     FSQYLHENAS YVRPLEEGML QLFESITEDT VTVLETTVKL KSFSDHLTSY VCFLRKILPY
     QFKSLEEECE SSLCTAALRA RNMELQNDMK KLTAVFEKLH TYINLLALPS TKPDRLLRTN
     FSSVFTYIAS TLHGFHDVLQ DMYKHYSQKA ALEQELPTAT QKLITTNDCI LSSIVALTNG
     AGKVASFFSN NLDCFTASLS YGPKGGMEFI SPLSAECMLQ NKKKAAAFMK LLKKPCPDSV
     PYEEALANRR VLLSSTESRE GLAQQVQQSL EKITKLEQEK EHWMLEAQLA KIRLEKENKK
     VIKNSVGNQR TEATQESLLT AELAEQEKED SMEKASMEAV TSTSLVGMLT VTTGDEEIPE
     AASREDLIKN HYMARIVELT SQLQLADSKS VHFHAECRAL AKRLSLADKS KESTLEDMRL
     AKQSITRLQD ELATTKRSYE DQLSMMSDHL CSMNETLSKQ REEIDTLKMA NKGNSKKNKS
     R
//