ID G1KPX8_ANOCA Unreviewed; 231 AA.
AC G1KPX8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Tetraspanin {ECO:0000256|RuleBase:RU361218};
GN Name=TSPAN18 {ECO:0000313|Ensembl:ENSACAP00000014212.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000014212.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000014212.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000014212.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000014212.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361218}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361218}.
CC -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC {ECO:0000256|ARBA:ARBA00006840, ECO:0000256|RuleBase:RU361218}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361218}.
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DR RefSeq; XP_008103703.2; XM_008105496.2.
DR RefSeq; XP_016847897.1; XM_016992408.1.
DR RefSeq; XP_016847899.1; XM_016992410.1.
DR RefSeq; XP_016847902.1; XM_016992413.1.
DR AlphaFoldDB; G1KPX8; -.
DR STRING; 28377.ENSACAP00000014212; -.
DR Ensembl; ENSACAT00000014503.4; ENSACAP00000014212.3; ENSACAG00000014461.4.
DR GeneID; 100556164; -.
DR KEGG; acs:100556164; -.
DR CTD; 90139; -.
DR eggNOG; KOG3882; Eukaryota.
DR GeneTree; ENSGT00940000157667; -.
DR HOGENOM; CLU_055524_4_1_1; -.
DR TreeFam; TF352892; -.
DR Proteomes; UP000001646; Chromosome 1.
DR Bgee; ENSACAG00000014461; Expressed in lung and 14 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd03156; uroplakin_I_like_LEL; 1.
DR Gene3D; 1.10.1450.10; Tetraspanin; 1.
DR InterPro; IPR018499; Tetraspanin/Peripherin.
DR InterPro; IPR000301; Tetraspanin_animals.
DR InterPro; IPR018503; Tetraspanin_CS.
DR InterPro; IPR008952; Tetraspanin_EC2_sf.
DR PANTHER; PTHR19282; TETRASPANIN; 1.
DR PANTHER; PTHR19282:SF249; TETRASPANIN-18; 1.
DR Pfam; PF00335; Tetraspanin; 1.
DR PIRSF; PIRSF002419; Tetraspanin; 1.
DR PRINTS; PR00259; TMFOUR.
DR SUPFAM; SSF48652; Tetraspanin; 1.
DR PROSITE; PS00421; TM4_1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361218};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transmembrane {ECO:0000256|RuleBase:RU361218};
KW Transmembrane helix {ECO:0000256|RuleBase:RU361218}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 56..77
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
FT TRANSMEM 84..108
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361218"
SQ SEQUENCE 231 AA; 26386 MW; 60E4F2C4E56D1986 CRC64;
MEGDCLSCMK YLMFVFNFFI FLGGTCLLGV GIWVIVDPTG FREIVATNPL LFTGAYIMLA
MGVMLFLLGF LGCCGAIREN KCLLLFFFMF ILLIFLAELS AAILAFIFRE NLTREFFTKE
LKKHYQGSNE SDVFSSTWNS VMITFGCCGV NGAEDFETAP RFLLLHSHNE VPEACCRREL
QSRDGAIIRK EDCLQGKEMY QNRQGCYTVI LNSFETYVYL CRSSCHWCFS H
//
