ID G1KQE4_ANOCA Unreviewed; 455 AA.
AC G1KQE4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE SubName: Full=GA binding protein transcription factor subunit alpha {ECO:0000313|Ensembl:ENSACAP00000014604.2};
GN Name=GABPA {ECO:0000313|Ensembl:ENSACAP00000014604.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000014604.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000014604.2, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000014604.2,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000014604.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_003219119.1; XM_003219071.3.
DR RefSeq; XP_008105841.1; XM_008107634.2.
DR RefSeq; XP_016847996.1; XM_016992507.1.
DR RefSeq; XP_016847997.1; XM_016992508.1.
DR AlphaFoldDB; G1KQE4; -.
DR STRING; 28377.ENSACAP00000014604; -.
DR Ensembl; ENSACAT00000014900.4; ENSACAP00000014604.2; ENSACAG00000014800.4.
DR GeneID; 100558009; -.
DR KEGG; acs:100558009; -.
DR CTD; 2551; -.
DR eggNOG; KOG3806; Eukaryota.
DR GeneTree; ENSGT00940000155799; -.
DR HOGENOM; CLU_037064_0_0_1; -.
DR InParanoid; G1KQE4; -.
DR OMA; YSFWLQD; -.
DR OrthoDB; 3915960at2759; -.
DR TreeFam; TF350537; -.
DR Proteomes; UP000001646; Chromosome 3.
DR Bgee; ENSACAG00000014800; Expressed in forelimb bud and 13 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0045653; P:negative regulation of megakaryocyte differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd08534; SAM_PNT-GABP-alpha; 1.
DR CDD; cd17039; Ubl_ubiquitin_like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR024668; GABP_asu_N.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR016312; TF_GA-bd_asu.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF195; GA-BINDING PROTEIN ALPHA CHAIN; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF11620; GABP-alpha; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PIRSF; PIRSF001703; GABP_alpha; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 168..251
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 321..401
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 297..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 455 AA; 51483 MW; 5E99726C4C5D2B77 CRC64;
MTKREAEELI EIEIDGTEKQ ECTEESIVEQ TYTTVEFVSQ AIDINEPVGN LKKLLEPRLQ
CSLEAHEICL QDIQLDPDRS LFDQGVKTDG TVQLSVQVIS RQGIEPKLNI LEIVKPVETV
EVVIDPDAHH TETEAHLVEE AQVITLDGTK HITTISDETS EQVTRWAAAL EGYRKEQERL
GIPYDPVQWS TDQVLHWVVW VMKEFSMTDI DLNTLSIPGR ELCSLSQEDF FQRVPRGEIL
WSHLELLRKY VLASQEHSGE IATVTIDQPV QIIPASVQPS TPTTIKVINS NAKAAKVQRA
PRISGEDRSS PGNRTGNNGQ IQLWQFLLEL LTDKDARDCI SWVGDEGEFK LNQPELVAQK
WGQRKNKPTM NYEKLSRALR YYYDGDMICK VQGKRFVYKF VCDLKTLIGY SAAELNRLVT
ECEQKKLAKM QLHGIAQPVT AVALATASLQ TEKDN
//
