ID   G1KQF2_ANOCA            Unreviewed;       542 AA.
AC   G1KQF2;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=XK-related protein {ECO:0000256|RuleBase:RU910716};
GN   Name=XK {ECO:0000313|Ensembl:ENSACAP00000014627.2};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000014627.2, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000014627.2, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000014627.2,
RC   ECO:0000313|Proteomes:UP000001646};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000014627.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU910716}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU910716}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000256|ARBA:ARBA00008789,
CC       ECO:0000256|RuleBase:RU910716}.
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DR   AlphaFoldDB; G1KQF2; -.
DR   STRING; 28377.ENSACAP00000014627; -.
DR   Ensembl; ENSACAT00000014923.3; ENSACAP00000014627.2; ENSACAG00000014890.3.
DR   eggNOG; ENOG502QTTF; Eukaryota.
DR   GeneTree; ENSGT00390000003231; -.
DR   HOGENOM; CLU_037429_1_1_1; -.
DR   InParanoid; G1KQF2; -.
DR   TreeFam; TF331465; -.
DR   Proteomes; UP000001646; Chromosome 3.
DR   Bgee; ENSACAG00000014890; Expressed in testis and 1 other cell type or tissue.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR   InterPro; IPR018629; XK-rel.
DR   PANTHER; PTHR14297:SF8; ENDOPLASMIC RETICULUM MEMBRANE ADAPTER PROTEIN XK; 1.
DR   PANTHER; PTHR14297; MEMBRANE TRANSPORT PROTEIN XK FAMILY MEMBER; 1.
DR   Pfam; PF09815; XK-related; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU910716};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU910716};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU910716}.
FT   TRANSMEM        102..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU910716"
FT   TRANSMEM        133..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU910716"
FT   TRANSMEM        264..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU910716"
FT   TRANSMEM        303..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU910716"
FT   TRANSMEM        332..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU910716"
FT   TRANSMEM        374..395
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU910716"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU910716"
FT   TRANSMEM        447..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU910716"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   542 AA;  60898 MW;  E6CE05E13E03AB87 CRC64;
     MKRGGGGGAR GLEPPGRKAA AASLLGEDPT NPSGAPRPIG RPAPHPPQAL PLGWRPSLAW
     FWVLRPSHGR RRGSASSSAS AWAPVLSRGT ERSESARMKF PGSVLVSLFL FVAETACALY
     LSSTYCSAGD RIWQSLTLLF ALLPCVLVQF SLVFVHRDLS RDRPLVLLLH ILQLGPIVRC
     VEVFCIYFQA GRVEEPYVSI TKKRQMPKDG HSDEIEKEVG QAEGKLFTHR SAFSRASVIQ
     AFLGSAPQLT LQLYICVLQQ EITAARSIFM TLSLLSIVYG ALRCNILAIK IKYDDYDVNI
     KPMAYLCIFL WRSFEIATRV IVLVLFSSVL QIWTLPVVLV NFFAFFFHPW ILFWQSKCTL
     PENIEKALSK VGTTIVLCLL TFLYAGINMF CWSAVHLKLN DADLIDKSQN WCRLALYYLL
     RFLENAFLLL MWYMYKTDVY TYVCAPMLFL QLLIGYCIAV LFMLAFYQFC HPCKKLFSSN
     ISEGLVLCFK FFCYICKPLG SSASVEKADL KSQEDFENDT VASYKTNETQ NGNAHQSVSS
     NA
//