ID G1KQF7_ANOCA Unreviewed; 719 AA.
AC G1KQF7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Kinesin-like protein {ECO:0000256|RuleBase:RU000394};
GN Name=kif2c {ECO:0000313|Ensembl:ENSACAP00000014636.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000014636.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000014636.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000014636.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000014636.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283,
CC ECO:0000256|RuleBase:RU000394}.
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DR RefSeq; XP_003220255.1; XM_003220207.3.
DR AlphaFoldDB; G1KQF7; -.
DR STRING; 28377.ENSACAP00000014636; -.
DR Ensembl; ENSACAT00000014932.4; ENSACAP00000014636.3; ENSACAG00000014854.4.
DR GeneID; 100558145; -.
DR KEGG; acs:100558145; -.
DR CTD; 11004; -.
DR eggNOG; KOG0246; Eukaryota.
DR GeneTree; ENSGT00940000165325; -.
DR HOGENOM; CLU_001485_19_1_1; -.
DR InParanoid; G1KQF7; -.
DR OrthoDB; 239968at2759; -.
DR TreeFam; TF105222; -.
DR Proteomes; UP000001646; Chromosome 4.
DR Bgee; ENSACAG00000014854; Expressed in dewlap and 11 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR CDD; cd01367; KISc_KIF2_like; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47971:SF19; KINESIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR47971; KINESIN-RELATED PROTEIN 6; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Microtubule {ECO:0000256|RuleBase:RU000394};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283,
KW ECO:0000256|RuleBase:RU000394};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 257..587
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT COILED 190..217
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 593..663
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 692..719
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 347..354
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 719 AA; 81583 MW; 13F1CD723BD81E5F CRC64;
MESSALYGCL QHGLTISIQR SNGVIHDATI KNVNWEKMFV SVEWTETSTI KGKEIDFDDV
VAINPELLKT PVAADGKESL PLQENVTTQS QNPRATVSRI PAPREALRYQ ASKMSVITES
QNNALESNME VESPAPMPPR IRSYLPVVRA RSRSSYCSDR CSIQPNGNGM IEEPPQSLRI
VSAAIQARRK STIVKEMEKM KNKREEKRAQ YSEIRNKRAQ EYDSSCPNWD FARMVKEYRA
TLNCQPISMN DPIEEHRICV CVRKRPLNRQ EIAKKECDVI TVISKNNILV HEPKVKVDLT
KYLENQPFRF DFSFDEKASN EMVYWFTARP LLQTIFEGGK ATCFAYGQTG SGKTHTMGGD
FSGKTQKASK GIYAFASQDV FLLLQQTRYK VQGLEVYVTF FEIYNGKLFD LLNKKAKLRV
LEDGKQQVQV VGLQEVRVNC AEDVIRIIEA GSACRTSGHS FANSNSSRSH ACFQIILRRK
GKLHGKFSLV DLAGNERGAD TSSADRQTRM EAAEINKSLL ALKECIRALG QNKQHTPFRE
SKLTQVLRDS FIGTNSRTCM IAMISPGMNS CEYTLNTLRY ADRVKELPHN GTADEAQNCM
ETENKELEIS EEESNHFLEL SEEELSPHLS SVREALTRIN ELEDKAIEEL KEIRQKMNAC
NDLLDIAEQP EYDLEAFVYE AQCFINEGSK SFETLKETLD ELTLAMQMEE QASKHLNKR
//
