ID G1KRL4_ANOCA Unreviewed; 341 AA.
AC G1KRL4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Glutaredoxin 3 {ECO:0000313|Ensembl:ENSACAP00000015513.3};
GN Name=GLRX3 {ECO:0000313|Ensembl:ENSACAP00000015513.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000015513.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000015513.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000015513.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000015513.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003218624.1; XM_003218576.2.
DR AlphaFoldDB; G1KRL4; -.
DR STRING; 28377.ENSACAP00000015513; -.
DR Ensembl; ENSACAT00000015827.4; ENSACAP00000015513.3; ENSACAG00000015736.4.
DR GeneID; 100556046; -.
DR KEGG; acs:100556046; -.
DR CTD; 10539; -.
DR eggNOG; KOG0911; Eukaryota.
DR GeneTree; ENSGT00550000075030; -.
DR HOGENOM; CLU_026126_12_2_1; -.
DR InParanoid; G1KRL4; -.
DR OrthoDB; 1038at2759; -.
DR TreeFam; TF314151; -.
DR Proteomes; UP000001646; Chromosome 3.
DR Bgee; ENSACAG00000015736; Expressed in embryonic post-anal tail and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:1990229; C:iron-sulfur cluster assembly complex; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0044571; P:[2Fe-2S] cluster assembly; IEA:Ensembl.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:Ensembl.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IBA:GO_Central.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:Ensembl.
DR CDD; cd03028; GRX_PICOT_like; 2.
DR CDD; cd02984; TRX_PICOT; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR InterPro; IPR002109; Glutaredoxin.
DR InterPro; IPR033658; GRX_PICOT-like.
DR InterPro; IPR004480; Monothiol_GRX-rel.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR NCBIfam; TIGR00365; Grx4 family monothiol glutaredoxin; 2.
DR PANTHER; PTHR10293; GLUTAREDOXIN FAMILY MEMBER; 1.
DR PANTHER; PTHR10293:SF73; GLUTAREDOXIN-3; 1.
DR Pfam; PF00462; Glutaredoxin; 2.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 3.
DR PROSITE; PS51354; GLUTAREDOXIN_2; 2.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 8..123
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
SQ SEQUENCE 341 AA; 37712 MW; 2C3DADF2C7BA8E66 CRC64;
MAERGGGGGG GGGSSAGSLV EATSAVQFHD LLQQPGRFLV VVHFWAPWAP QCVQMNTVMA
ELAKEHPRVT FVKLEAEAVP EVSEKYEITS VPTFLFFKNS QKIDQLDGAH APELTKKVQR
HASSVTVPTS SNDTSKEDLN ARLKKLTNAA PCMLFMKGTP QEPRCGFSRQ IIEILNKHNV
VFSSFDIFSD EEVRQGLKAY SNWPTYPQLY VAGELIGGLD IVKELEASGE LNTVCPKAHK
LEDRLKDLIN KASVMLFMKG NKQTAKCGFS KQIIEILNNS GVDYDTFDIL EDEEVRQGLK
KYSNWPTYPQ LYVKGELIGG LDIVKELKEN GELSSILKGE N
//
