ID G1KS64_ANOCA Unreviewed; 1407 AA.
AC G1KS64;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Erbb2 interacting protein {ECO:0000313|Ensembl:ENSACAP00000015857.4};
GN Name=ERBIN {ECO:0000313|Ensembl:ENSACAP00000015857.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000015857.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000015857.4, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000015857.4,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000015857.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003216387.2; XM_003216339.3.
DR STRING; 28377.ENSACAP00000015857; -.
DR Ensembl; ENSACAT00000016174.4; ENSACAP00000015857.4; ENSACAG00000016015.4.
DR GeneID; 100556172; -.
DR KEGG; acs:100556172; -.
DR CTD; 55914; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000159526; -.
DR HOGENOM; CLU_004220_1_0_1; -.
DR TreeFam; TF351429; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000016015; Expressed in forelimb bud and 13 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd00992; PDZ_signaling; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR23119; DISCS LARGE; 1.
DR PANTHER; PTHR23119:SF46; ERBB2-INTERACTING PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00364; LRR_BAC; 10.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1317..1406
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 463..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 559..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..478
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 559..582
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1083
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1143..1171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1407 AA; 157556 MW; 5A63186C31106E97 CRC64;
MTTKRNLFVR LVPCRCLRGE EETVTALDYS HCSLEQVPKE IFTFEKTLEE LYLDANQIEE
LPKQLFNCQS LHKLSLPDND LTTLPASIAN LINLRELDVS KNGIQEFPEN IKNCKVLAIV
EASVNPISKL PDGFSQLLNL TQLYLNDAFL EFLPANFGRL TKLQILELRE NQLKMLPKTM
NRLTQLERLD LGSNEFTEVP EVLEQLSGLK EFWMDGNRLT LIPGFMGSLK HLIYLDVSKN
NIETLEEGIS GCESLQDLLL SSNSLQQLPE SIGCLKKLAI LKIDENQLMY LPDSIGGLTS
VEELDCSFNE IEALPSSVGQ LSNIRTFAAD HNFLTQLPPE IGNWKYVTVL FLHSNKLEFL
PEEMGDMQKL KVINLSDNRL KYLPYSFTKL QQLTAMWLSD NQSKPLIPLQ KEVESETQKT
VLTNYMFPQQ PRSEDVMFIS DNESFNPSLW EEQRKQRAQV AFECDEDKDE REAPPREGNL
KRYPTPYPDE LKNMVKTVQT IVHRLKDEEN TEDTSKETKP ENQQVIVKDV GVKTSEVTPV
KNKMENEHNI MGNCVQKLNE SDADNSSGNV QTSAQVKTSE NTKPIANHED ILEHESEDLS
SDEEMKIAEM RPPLIETSIN QPKVVALGSS KKDDSKDMDS LSDDPTHNSN QNNSNCSSPS
RMSDSVSLNT DSSREASLSS PDKEINLAVS SKIRQEDENY NSLLQNGGEI NVTAEEKLDV
QNAVTNFSEF RFSIEEKLAL IERGVELTSA TDESHKLHQI NKNICKLTEE ERTQPNVQEE
IKTQEISVKG FLNNNNKEVI EHLENGNRYS NLCPLNNVNG HSDEVPLSSG RSELKRSATI
ETDSSSEMGL SKSTEDLSPQ RSGPVVKSHS ITNMETGALK IYDIINDSGS QQQTPVVKST
AIVPEGKNIV RSKSATLLYD QPLQVFSGCS SSSDLISTKT VFKFDSNHNP EGTSMIKGQG
TNTSQPFSPP QYNIQYSSSI AAKESLWPPK QNSLVEQSCL PPQRLPRSET VDSCNSVKHS
ANMNFSNHNN VRATAAYTMH QRMGGRHAEM WAVPPNDRLV SGATRNTLQR QSSVSSTASM
NVADSGPPRR PPVPERDYLT YRDLHSMGRV PPMMSGPQRP LSARTYSVDG PNVPRPQSAR
PSPNEIPERT MSVSDFNYSR TSPSKRANPR VNSEHSLLDP PGKSKVPPDW REQVLRHIEA
KKLEKHPQTS IPGDQCQEDV FISGQQNYTS TPLSLKDVAP DSIKKLPVQI PLTNGQMCQP
PRPQANYSQV HHAAPQASVA RHPSREQLID YLMLKVAHQP PYTQAQGPVR HELSKHEMRV
RIEKDPELGF SISGGIGGRG NPFKPDDDGI FVTRVQPEGP ASKLLQPGDK IIQANGYSFI
NIDHGHAVSL LKTFQNTVEL IIVRELS
//
