ID G1KSG8_ANOCA Unreviewed; 572 AA.
AC G1KSG8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSACAP00000016060.3};
GN Name=mcoln1 {ECO:0000313|Ensembl:ENSACAP00000016060.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000016060.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000016060.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000016060.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000016060.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_008101993.1; XM_008103786.2.
DR AlphaFoldDB; G1KSG8; -.
DR STRING; 28377.ENSACAP00000016060; -.
DR Ensembl; ENSACAT00000016380.4; ENSACAP00000016060.3; ENSACAG00000016313.4.
DR GeneID; 100554932; -.
DR KEGG; acs:100554932; -.
DR CTD; 57192; -.
DR eggNOG; KOG3733; Eukaryota.
DR GeneTree; ENSGT00950000183036; -.
DR HOGENOM; CLU_020945_1_1_1; -.
DR OrthoDB; 2877219at2759; -.
DR TreeFam; TF317783; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000016313; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IBA:GO_Central.
DR CDD; cd21070; ELD_TRPML1; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR047316; ML1_ELD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF6; MUCOLIPIN-1; 1.
DR Pfam; PF21381; MCLN_ECD; 1.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..368
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 420..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..509
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 85..280
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 381..516
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 7..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 65604 MW; F95B9152242C7FFC CRC64;
METQKLLSSM NSYGSQDGDT RPVLGPPSFH PEEEELRRRL KYFFMSPCDK FRAKGRKPFK
LVLQLIKIII VTVQLILFGL SNQMVVTFKE ENTITFKHLF LKDYADGAED AYAVYTQADV
YDHMFYAVDK YLSVQNETIG RYAYVRTHGV NQSALMLCQQ YYRKGSIDPA NDTFNIDPKV
ITECLGVDPP GKIPSSLDLE ESPPNTEEPD RSYRNFTLKF YKLINVTIQF KLKAINIQTI
INNEIPDCYT FSITITLDNK AHSGRVKIHL DNKVDIQECK DPSVYGKGGN GFRMFFDVIV
LLICVLSFIL CSRSIFRGLL LQHEFTQFFQ HRYNQDICLS DRMEFVNGWY ILLVVSDIMT
ISGTIMKIGI ESKNFANYDV CGILLGTSTL LVWVGVMRYL SFFQKYNILI VTMRVAFPNV
IRFCCCVAVI YLGYCFCGWI VLGPYHVKFR TLSMVSECLF SLINGDDMFV TFASMQQSSY
LVWLFSQVYL YTFISLFIYM VLSLFIALIT GSYETIKHQS EGEATVTQLH AYIAECKDSP
KSGKFRRESA SSCSIFCCCE RTPLQENVLV VN
//
