ID G1KSZ3_ANOCA Unreviewed; 591 AA.
AC G1KSZ3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Solute carrier family 13 member 3 {ECO:0000313|Ensembl:ENSACAP00000016440.3};
GN Name=SLC13A3 {ECO:0000313|Ensembl:ENSACAP00000016440.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000016440.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000016440.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000016440.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000016440.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC NADC subfamily. {ECO:0000256|ARBA:ARBA00006772}.
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DR AlphaFoldDB; G1KSZ3; -.
DR Ensembl; ENSACAT00000016765.4; ENSACAP00000016440.3; ENSACAG00000016711.4.
DR eggNOG; KOG1281; Eukaryota.
DR GeneTree; ENSGT01030000234550; -.
DR HOGENOM; CLU_005170_9_1_1; -.
DR InParanoid; G1KSZ3; -.
DR TreeFam; TF312913; -.
DR Proteomes; UP000001646; Chromosome 4.
DR Bgee; ENSACAG00000016711; Expressed in kidney and 7 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0015139; F:alpha-ketoglutarate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015137; F:citrate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0034634; F:glutathione transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015362; F:high-affinity sodium:dicarboxylate symporter activity; IEA:Ensembl.
DR GO; GO:0017153; F:sodium:dicarboxylate symporter activity; IBA:GO_Central.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015746; P:citrate transport; IBA:GO_Central.
DR CDD; cd01115; SLC13_permease; 1.
DR InterPro; IPR001898; SLC13A/DASS.
DR PANTHER; PTHR10283; SOLUTE CARRIER FAMILY 13 MEMBER; 1.
DR PANTHER; PTHR10283:SF62; SOLUTE CARRIER FAMILY 13 MEMBER 3; 1.
DR Pfam; PF00939; Na_sulph_symp; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Sodium {ECO:0000256|ARBA:ARBA00023201};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023201}.
FT TRANSMEM 17..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 112..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 145..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 533..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 591 AA; 65834 MW; E97ACAEF899A15DA CRC64;
MAALGALVKK VWSLRRYLVL LGTPLVLLPI LFSLPPKEGK CLYVILVMAT YWCTEALPLS
VTALLPIILF PFLGILPANK VCPQYFLDTN FLFLSGLIMA AAIEEWNLHR RIALRILILV
GVQPARLILG MMLTTSFLSM WLSNTASTAM MLPIAMAILK SLFGEKETSR DLKKEKEEIQ
VCTLQNKLHM VPTEMQLLAN VDEKDLIEEK VTIEVSSDVR KEEEYKTNVW KGFLISIPYS
ASIGGTATLT GTAPNLILSG QLKSYFPGCD LVNFGSWFVF AFPLMVLFLF LGWLWISFLY
GCISLRGCRK KKSEIRADAE ARARAVITED YQKLGPIKFA EQAVFVLFCL FAILLFSRDP
KFITGWASLF TPGFVTDAVT GVTIVTILFF FPSKRPTLKW WFDLKAVRKD FPYEVQMCKS
LTQPFRFSSL LQESGLSSWI GGRLGPLENL PPPVAVILIT IVIALFTEFA SNTATIIIFL
PVLAELAIRL KVNPLYLMIP GTIGCSFAFM LPVSTPPNSI AFASGHLMVK DMARTGLLMN
LMGVLLLSLA INTWGMSIFQ LGTYPAWANI HSSENITTLL VDVQNTTLKS L
//
