ID   G1KTC1_ANOCA            Unreviewed;       445 AA.
AC   G1KTC1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 3.
DT   27-MAR-2024, entry version 73.
DE   SubName: Full=Protein kinase C substrate 80K-H {ECO:0000313|Ensembl:ENSACAP00000016676.4};
GN   Name=PRKCSH {ECO:0000313|Ensembl:ENSACAP00000016676.4};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000016676.4, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000016676.4, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000016676.4,
RC   ECO:0000313|Proteomes:UP000001646};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000016676.4}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; G1KTC1; -.
DR   STRING; 28377.ENSACAP00000016676; -.
DR   Ensembl; ENSACAT00000017006.4; ENSACAP00000016676.4; ENSACAG00000016939.4.
DR   eggNOG; KOG2397; Eukaryota.
DR   GeneTree; ENSGT00510000047770; -.
DR   HOGENOM; CLU_016834_1_0_1; -.
DR   TreeFam; TF329550; -.
DR   Proteomes; UP000001646; Chromosome 2.
DR   Bgee; ENSACAG00000016939; Expressed in kidney and 13 other cell types or tissues.
DR   GO; GO:0017177; C:glucosidase II complex; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0001889; P:liver development; IBA:GO_Central.
DR   GO; GO:0006491; P:N-glycan processing; IBA:GO_Central.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR039794; Gtb1-like.
DR   InterPro; IPR028146; PRKCSH_N.
DR   PANTHER; PTHR12630:SF1; GLUCOSIDASE 2 SUBUNIT BETA; 1.
DR   PANTHER; PTHR12630; N-LINKED OLIGOSACCHARIDE PROCESSING; 1.
DR   Pfam; PF12999; PRKCSH-like; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..445
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5032881503"
FT   DOMAIN          212..247
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REGION          204..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          297..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..221
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        314..336
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        337..359
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   445 AA;  49656 MW;  5A0541F0307929A9 CRC64;
     MLLLSLVLLL LSGLASSVEV KRPRGVSLTN HHFYDESKPF TCLDGSATIH FDRVNDDYCD
     CKDGSDEPGT PACPNGRFHC SNAGYRPQYI PSSRINDGIC DCCDATDEYN SGIVCENTCK
     EMGRKEREAL KQKAEVAREG FEIKKALMEE ASKRKEEKQK KLVELQEGKK SVEEQVETLR
     AQKEAAEKPE KEAKDIHQKA WEEQKEAERA ARDQAKAEEA FMELDDDGDG IVSVAELQTH
     PELDVDGDGI LSETEAQTLL DNSLQVDVGS FQNTVWNAIK EKYKAESLVD VQSPLKGTAE
     EEPDNQSDSQ LDQLPPEEDY EEDDDEEEET DEDSIDEELK VPPPKPSSDV KAAAEEEEQE
     KMPPYDEATQ SLIDGTWRKR SPLILDLMEN FHICTASAMI LPQMSTFIVS VPLTECLRNP
     STVARRPALA RGVPGLVLKR TNSVS
//