ID G1KTD4_ANOCA Unreviewed; 338 AA.
AC G1KTD4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Protein Wnt {ECO:0000256|RuleBase:RU003500};
GN Name=WNT8A {ECO:0000313|Ensembl:ENSACAP00000016713.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000016713.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000016713.2, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000016713.2,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000016713.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Ligand for members of the frizzled family of seven
CC transmembrane receptors. {ECO:0000256|RuleBase:RU003500}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498, ECO:0000256|RuleBase:RU003500}.
CC -!- SIMILARITY: Belongs to the Wnt family. {ECO:0000256|ARBA:ARBA00005683,
CC ECO:0000256|RuleBase:RU003500}.
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DR AlphaFoldDB; G1KTD4; -.
DR STRING; 28377.ENSACAP00000016713; -.
DR Ensembl; ENSACAT00000017043.2; ENSACAP00000016713.2; ENSACAG00000016983.2.
DR eggNOG; KOG3913; Eukaryota.
DR GeneTree; ENSGT00940000157840; -.
DR HOGENOM; CLU_033039_1_2_1; -.
DR InParanoid; G1KTD4; -.
DR OrthoDB; 2874082at2759; -.
DR TreeFam; TF105310; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000016983; Expressed in embryonic post-anal tail.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0005109; F:frizzled binding; IBA:GO_Central.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR GO; GO:0048561; P:establishment of animal organ orientation; IEA:Ensembl.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0009949; P:polarity specification of anterior/posterior axis; IEA:Ensembl.
DR GO; GO:0010085; P:polarity specification of proximal/distal axis; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR Gene3D; 3.30.2460.20; -; 1.
DR InterPro; IPR005817; Wnt.
DR InterPro; IPR013301; Wnt8.
DR InterPro; IPR043158; Wnt_C.
DR InterPro; IPR018161; Wnt_CS.
DR PANTHER; PTHR12027:SF92; PROTEIN WNT-8A; 1.
DR PANTHER; PTHR12027; WNT RELATED; 1.
DR Pfam; PF00110; wnt; 1.
DR PRINTS; PR01892; WNT8PROTEIN.
DR PRINTS; PR01349; WNTPROTEIN.
DR SMART; SM00097; WNT1; 1.
DR PROSITE; PS00246; WNT1; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU003500};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687,
KW ECO:0000256|RuleBase:RU003500}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 338 AA; 37621 MW; 3DE2FD8977380A71 CRC64;
MKGSIFIILI TIGIYSGIFN TSAYLTYSTS VAAGAHLGIE ECKFQFAWER WNCPESALQL
STHYKLRSAT RETSFVHAIS SAGVMYTLAR NCSMGDFESC SCDSSRNGHV GGKGWIWGGC
SDNVEFAEKI SKHFVDALET GHDTRALMNL HNNEAGRLAV KSTMKRTCKC HGVSGSCNIQ
TCWLQLADFR EIGSYLKTKY DQAQKLEMDK NRIRAGNSAE SRGAKNEAFG SVPSTNLVFL
EDSPDYCTIN VSLGLRGTEG RECLQGGKKR SCKKVCLDCG LKIEETRTEV VSSCNCKFLW
CCTVKCQQCK QVVTKYYCSR SESFSSNNIR KRNRAPRR
//
