ID G1KTE7_ANOCA Unreviewed; 1176 AA.
AC G1KTE7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Tubulin--tyrosine ligase-like protein 5 {ECO:0000256|ARBA:ARBA00041448};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000016738.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000016738.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000016738.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000016738.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L-
CC glutamyl-L-glutamyl-[protein] + H(+) + phosphate;
CC Xref=Rhea:RHEA:60144, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15517,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143622,
CC ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036640};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60145;
CC Evidence={ECO:0000256|ARBA:ARBA00036640};
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DR AlphaFoldDB; G1KTE7; -.
DR STRING; 28377.ENSACAP00000016738; -.
DR Ensembl; ENSACAT00000017068.4; ENSACAP00000016738.3; ENSACAG00000016982.4.
DR eggNOG; KOG2157; Eukaryota.
DR eggNOG; KOG2158; Eukaryota.
DR GeneTree; ENSGT00940000162910; -.
DR HOGENOM; CLU_006704_1_0_1; -.
DR InParanoid; G1KTE7; -.
DR TreeFam; TF313087; -.
DR Proteomes; UP000001646; Chromosome 1.
DR Bgee; ENSACAG00000016982; Expressed in hindlimb bud and 13 other cell types or tissues.
DR GO; GO:0097731; C:9+0 non-motile cilium; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0005929; C:cilium; IBA:GO_Central.
DR GO; GO:0015631; F:tubulin binding; IBA:GO_Central.
DR GO; GO:0070740; F:tubulin-glutamic acid ligase activity; IBA:GO_Central.
DR GO; GO:0009566; P:fertilization; IEA:Ensembl.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0007288; P:sperm axoneme assembly; IEA:Ensembl.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR PANTHER; PTHR12241:SF145; TUBULIN POLYGLUTAMYLASE TTLL5; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT REGION 550..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 739..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 787..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..568
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..600
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 601..615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1176 AA; 132780 MW; 4E7B9CB3ABDC9A17 CRC64;
DSFVTSSDLV EHPCITWTGG FRRIPILVFH ADAIITKDSY TRLIGERYRL AFKIVRTDSR
LVRSILSAHG FREVHPSSNE YNLMWTGSHL KPYVLRSLTD IQKVNHFPRS YELTRKDRLY
KNINRMQQTY GFKSFHVLPQ TFILPAEYQE FCNSYAKDRG PWIVKPVASS RGRGVYLINS
PNQISLEENI LVSRYINNPL LIDDFKFDVR LYVLVTSYDP LLVYLYEEGL ARFATVRYDQ
GAKNIKNQFM HLTNYSVNKK SGDYVSCDDP EVEDYGNKWS MSAMLRYLKQ EGKDTTALMA
SVEDLIIKTI LSAELAIASA CKAFVPHRGV CFELYGFDVL IDSTLKPWLL EVNLSPSLAC
FINLETSFYS SEARRNPYQK PQRSRPLSAS DAEMKNLMSS AKEKIPGRHV GSMLGLSMEE
IKVLRRVKDE YERRGGFIRI FPTPITWDTY GSFLEHKTTM NYMLATRLFQ ERGGSRRCPI
LKRTRLALAG ELGLDVVDCN AQLHAALYER KLLSLEVRKR RRRHGKLRPR RSRLSGALQS
TDFALKSEME CEEEEETTEE DEEPEIPQNE TADCLKNMKV KSKPQLSEQV EPSHQGKLTK
NQLEQKPKSE ELPCESKLDT VPKSVELPFN LLQVLHENKN LSKVQARKAF SAYLHRVQLR
LMKEAGDQVH NPAWAAKEDE QMELVVRFLK RAASNLQQSL RMLLPSRRLA LFDRRRILAH
QLGEFIICYN RETDQMAQKK LKQKQEEEEE EGVDPEGFHE FVIKASESDL EEVLTFYTHK
NKSASVFLGT NPGTSKHSNS QLENRGKEGV TSSPEDENAP QLSFLSATSS SVPDAILPQS
ISPQLPSHTA ASDNAQLPDH LSGFSLSSGS RLIPSSSFQN AAMDSWSSTT KNVPQLSSNN
AGLHRCQSGS FTASPFSSFQ SAMQIYSQRL TRPSSAKAGK AAGYLRSAFA RVTKDGEECK
RFSHGVIAEE LHRLAEKQAT RQYCPPSHIN LLTQQLTNLN LMNGAVSRVN TTSSYRPSLN
PGGSFWAFQT HAHATDIRPA SLAVRFAWEG DAENSLHSKL IGSQPLHPKA SSSTGSYQLH
FALQQLQQQK LQSRQLLDQS RARHQSLPNS SITLSSGSGA RRTSSAISSS QKASTLHKVM
SSQSASSHLI PKPPASHRQT VIRKVASQRI SKHNTM
//
