ID G1KV10_ANOCA Unreviewed; 955 AA.
AC G1KV10;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000018176.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000018176.2, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000018176.2,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000018176.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G1KV10; -.
DR STRING; 28377.ENSACAP00000018176; -.
DR Ensembl; ENSACAT00000023214.2; ENSACAP00000018176.2; ENSACAG00000028117.2.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000163999; -.
DR HOGENOM; CLU_006000_4_0_1; -.
DR InParanoid; G1KV10; -.
DR TreeFam; TF351113; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000028117; Expressed in adrenal gland and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF551; LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00365; LRR_SD22; 8.
DR SMART; SM00369; LRR_TYP; 16.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 5.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..955
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5032450549"
FT DOMAIN 792..933
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 955 AA; 109275 MW; 7F7B8F9D3D283C0F CRC64;
MPFLGLVSIL ILLVNLHQNV TPYSLENCEI HDNAENETKV LCYHRNLSEV PAHLPSKVVF
LDLSENRIAS LRKNSFSNLI HLHVLNISQN QIHHIEEGAF VNTCHLEILN LTGNQLHLIS
SPMFAGLRNL TILLLGNNQI DKIETSAFVH LEKLKVIDLS SNRLHALNAM DAIFNMESLE
KLHIKDNNLQ NFSTKEIVSV PLILHELDAS HNPISVLDVS TPVLQSLVSL DLSFSTPKTP
IVWLIQDPCF LKGLKVLYLG GIAMNPSGIL EVIQTLNCSL LEIIYLDHLN LTESDGLIEQ
VCLSHQNIET LHLLGNKFTS VKARAFEKCT HLRHLNMAFN KLKVLPVSLF QSLPYLQILS
LAYNKFTLVP NATSNVASLE TLDLSFNKIK RISPDDFAHL NNVKSLYMTG NTISHVTSNL
FANLHRLQEL DLGENALKMI KEPFSASLQM LKTLILRQNK MDHITKGIFR NLASLQLLNL
ADNQIATIKP GAFEGLSNLQ SLILGSNKIT KETFHKGVFQ GASSLEDLEL FSNYMSYESS
QKLAYPPFHL LKSLKRLQIN SQRHDGLQNF PVNFLEGLES IVQIHAGNLA ISSLDSDTFK
YTPTLKELDL SNNNLNSISA TLFAPLSNLK ELHLNKNGLN SLSFVSQVNF SQLGLLRLAG
NQIDVVTREQ IKALPLLLFL DLRNNPFTCC CSNQDFLRWS PMNPKTQVLH FSEYTCASPP
AYKEKKLWTF KTSSCTANHD FILYITNTAA VILLMLVCFC CQWRWHMVYT YHLLLAYFID
KKQKRKGQDI EYNYDAFVSY NTRDEKWVMN YLLPVLENQY SWKLCLHHRD FEPGRFILEN
IVDNIYSSRK TICVISRHYL ESEWCSKEIQ VASFRIFDQH KDVLILIFLE DIPCEYLSPY
HRMRRLIKKK TYLKWPQEEQ EIQFFWHKLN MAMKTGEGKE EEHPIVAGFV FDEIP
//
