ID G1KV19_ANOCA Unreviewed; 825 AA.
AC G1KV19;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN Name=STAT2 {ECO:0000313|Ensembl:ENSACAP00000018198.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000018198.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000018198.2, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000018198.2,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000018198.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR RefSeq; XP_008102199.1; XM_008103992.2.
DR AlphaFoldDB; G1KV19; -.
DR STRING; 28377.ENSACAP00000018198; -.
DR Ensembl; ENSACAT00000025425.3; ENSACAP00000018198.2; ENSACAG00000023449.3.
DR GeneID; 103277767; -.
DR KEGG; acs:103277767; -.
DR CTD; 6773; -.
DR eggNOG; KOG3667; Eukaryota.
DR GeneTree; ENSGT01050000244905; -.
DR HOGENOM; CLU_014189_3_0_1; -.
DR OrthoDB; 7823at2759; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000023449; Expressed in lung and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006952; P:defense response; IBA:GO_Central.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043434; P:response to peptide hormone; IBA:GO_Central.
DR GO; GO:0060337; P:type I interferon-mediated signaling pathway; IBA:GO_Central.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF41; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 580..676
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 825 AA; 94905 MW; 5CA4423FACE6D12A CRC64;
MALWQKIQML DTVYLEQVHN LYMDERLPME VREYIAYWIE EQDWNQAAQF GSSLACCLFH
NMQSLLDDQL GRLVLSEENN SNIVLKHNLH RSKVHLQALY QDHPEQLAQV IDDLLKQERE
ILAAALAASQ PVVEAPVTAS MTSSQQEKIG ARLSEMRKAI QALKNSIDQL ELLQDTFDFR
FKTQRILEST VPNTDPGLIR RMQELQIMLN KVDRSRKEVL AQIQGLLGFF ETLRDLLLEE
REAWKDRQRQ ACIGNNCDTR LGQLEKWFTA NAEDLFHLLQ LLQTLKDLQQ KLTYDQDQLK
MCLPQLENRL KEQIIFLLKS AFVVEIQPTM PYPCRRPLVL RTNQKFSVRA RLLVKLMDRN
HPMEAKIEID RDSTNLAGFR KFNILTSTTK TLMMDRPQTE GLICDFKHIS LREQKISGSG
KGKGGKGISE GGLSVLEELH VITFTLDYWY QGLQCQLQTS TLPMIIISNV SQMSSAWASI
LWFIMLNRDP LNQRFFINPP AATWPQLSTV LSWQFSSATE KGLNADQLKM LGEKLCGSPV
TAQSIITWSQ FAKDSPPSFS FWTWIDGILL LIQENLLHLW KNDLIMGFVS RKRERHLLKK
KRGGTFLLRF SESTKSGGIT CTWVEYDDKG SPMFSAVEPY TREQLKVLPL PDIIRDYHVL
ADEVIPENPL QYLYPDTPRD EAFGPYYSER READLPEQRK YLTRRLISVS SSITNPSRQP
EEVQALDFLV ADSNASDFQD LELKAPDHHI PEASVPMVNG VVFENGIALP SELEEPEQGG
LLCNSQDPYL LQLEDEQYLG QVTSELFMPS EELQELKLDD EDLNF
//
