ID G1KV91_ANOCA Unreviewed; 1173 AA.
AC G1KV91;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=AF4/FMR2 family member 4 {ECO:0000313|Ensembl:ENSACAP00000018355.2};
GN Name=AFF4 {ECO:0000313|Ensembl:ENSACAP00000018355.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000018355.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000018355.2, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000018355.2,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000018355.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AF4 family. {ECO:0000256|ARBA:ARBA00007354}.
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DR RefSeq; XP_003217431.2; XM_003217383.3.
DR AlphaFoldDB; G1KV91; -.
DR STRING; 28377.ENSACAP00000018355; -.
DR Ensembl; ENSACAT00000024982.2; ENSACAP00000018355.2; ENSACAG00000022605.2.
DR GeneID; 100565688; -.
DR KEGG; acs:100565688; -.
DR CTD; 27125; -.
DR eggNOG; ENOG502QR32; Eukaryota.
DR GeneTree; ENSGT00950000182974; -.
DR HOGENOM; CLU_006484_0_0_1; -.
DR InParanoid; G1KV91; -.
DR OrthoDB; 4254515at2759; -.
DR TreeFam; TF326216; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000022605; Expressed in forelimb bud and 13 other cell types or tissues.
DR GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0032783; C:super elongation complex; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR Gene3D; 6.10.250.2670; -; 1.
DR InterPro; IPR007797; AF4/FMR2.
DR InterPro; IPR043640; AF4/FMR2_CHD.
DR InterPro; IPR043639; AF4_int.
DR PANTHER; PTHR10528; AF4/FMR2 FAMILY MEMBER; 1.
DR PANTHER; PTHR10528:SF15; AF4_FMR2 FAMILY MEMBER 4; 1.
DR Pfam; PF05110; AF-4; 1.
DR Pfam; PF18875; AF4_int; 1.
DR Pfam; PF18876; AFF4_CHD; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 911..1173
FT /note="AF4/FMR2 C-terminal homology"
FT /evidence="ECO:0000259|Pfam:PF18876"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 69..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1096
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..255
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..397
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..594
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..658
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 663..685
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..715
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..806
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 847..874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 875..889
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 890..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1096
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1173 AA; 128730 MW; 4AE146756671315C CRC64;
MSNMNREDRN ALRIKERERR NQEIQQGEEA FPPNSPLFAE PYKVTSKEDK LSSRIQSMLG
NYDEMTDIIG DRSLQKRCGM PKPTVPSTAD EKSNQSFFGD QRHSGGSHQS SKWTPVGPAP
STSSQSQKRS SGLQGGHGSQ RSSGNSTSSS GQRHDRDSYS SSGSSSSHKK AQHGSEHSKS
RSSSPGKPSA VSSLNPSHSR SHGGDHHSKE HQRSKSPRDP DANWDSPSRV HSFSSGNQSF
PPSLMSKSNT MLQKPTAYVR PMDGQESMEP KLSSEHYSSQ THSNNMNELK PSSKAHLTKL
KIPSQPLDAS ASGDMSSVDE ILKEMTHIWP PPLTAIHTPC KTEPSKFPFP TKDTQQSNFG
TGEQKRYNPS SKTSNGHQSK SCESNQTDVL INDLKLSSSE DSDGEQDSDK TVPRSTPGST
SEPSQHASEG ADNSRDDSSS HSGSESSSGS DSESESSSSD SEANEPSQSA SPEPEPPPTN
KWQLDNWLNK VNPHKVSPAS SVDSNIPSTQ GYKKEGRDQS GGGGYADQSG SKDSISSIPG
RDSKPSQKGS ESNRGRQKSP AQSESMTQRR TVGKKQPKKT EKASVEEPRG GLKIESETPM
EMTTSIPSNR HKAATKGSRK PNIKKEPKSS PRPTTEKKKC KVASKSTQKS KEFIETDTSS
SDSDENESLP PSSQTPRYSE SNRTPVKPSM EEDDSFLRQR MFSPMEEKEL LSPLSDPDER
YPLIVKIDLS LLTRIPGKPY KDTDPSKTER KNVSEKHPRE PQKTSSAEKS SNKGKRKHKL
CQNAEENRGT ESKKSKIEEK TSSVHKTSSN RESSKQSGVK EKDLLPSPAS TPVIQKDSKQ
EHGSRKRTVS QSSSLKSSSN SNKESNSSSK GSSSKQKKTE GKAPSNTKET KEKALNNTSS
CPSASSATAD SSKSRRAKMV FDDRTYSADH YLQQAKKLKH NADALSDRFE KAVYYLDAVV
SFIECGNALE KNAQESKSPF PMYSETVELI KYTMKLKNYS APDATSADKR LAVLCLRCQS
LLYLRLFKLK KESALKYSKT LTEHLKNSYN NSQAPSPGIG SKPVSMPSPV SPKLSPGNSG
NYSSGSTNPS GSTSSVTIPQ RIHQMAASYV QVTSNFLYAT EIWDQADQLA REQKEFFTEL
DKVMGPLIFN ASVMTDLVRY TRQGLHWLRL DAK
//
