ID G1KW10_ANOCA Unreviewed; 749 AA.
AC G1KW10;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000018995.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000018995.2, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000018995.2,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000018995.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
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DR AlphaFoldDB; G1KW10; -.
DR STRING; 28377.ENSACAP00000018995; -.
DR Ensembl; ENSACAT00000001805.3; ENSACAP00000018995.2; ENSACAG00000001836.3.
DR eggNOG; KOG0221; Eukaryota.
DR GeneTree; ENSGT00550000074977; -.
DR HOGENOM; CLU_002472_8_0_1; -.
DR TreeFam; TF314549; -.
DR Proteomes; UP000001646; Chromosome 1.
DR Bgee; ENSACAG00000001836; Expressed in brain.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003690; F:double-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0051026; P:chiasma assembly; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03281; ABC_MSH5_euk; 1.
DR Gene3D; 1.10.1420.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF20; MUTS PROTEIN HOMOLOG 5; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 581..597
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 749 AA; 84777 MW; 83E49048E1B7771D CRC64;
SFLDMSNPRR TFWSLFYIYE SKPLPITEQE DEQEQSEIYL CVLWYGGELG IAYYDTGDCS
IYFMAESPDN KDLKLLQKVV DEVLPTYILS SAKQDQSIAS FFTNIKTVTE EKQGERKPEV
VFYPNMDFGL EVSKQRILSR QFPFVPSHMT ATEKILYLSS VIPFESPLVV RALGGLLKFL
DRKRPGVELE DSHIAVPILA FKKFVLTDIV NVDQDTYCVL QIFKSEIHPS VYKQVSGKKE
GLSLYGILNH CRCKWGEKLM RLWFMRPTRN LTELNKRLDV IQFFLLARNH EIVLTLQECL
KNIKNVPLIL RRMALSNTKV SDWQALYKTV YSAVCLRNTC RSLPSTIDLF QTISQVFTDD
LHYIASLISK VVDFESSIAE NHFTVRPNVD AIIDEKKRKV MGLSDFLTDV TVDEDQETLI
MYQLQTKILE KSAVLNDVIE YTAHLDVLLS LAVMARENGY VRPHFSHSHM IRIKDGRHPL
MELCAKTFVP NSVESCETSG RIKILTGPNS SGKSIYLKQV GLITFMALIG SYVPAAEAEI
GAVDGIYTRI HSRESVSLGL STFMIDLNQV AKAVNNATER SLVLIDEFGK GTNTVDGLSL
LAAVLRYWIK QATNCPHIFV ATNFHSLVQL KLLPTTPLVQ YLTMDTHQDG DELVFFYQIK
EGVSTVSHAA NIAALAGMPP KVIARGIEVS ELLRNGKPIQ RPDHSSKEKQ LQNCKALVDK
FLSLDLDDPH LDLKEFMNKE VLPSSASIL
//
