ID G1KYN3_ANOCA Unreviewed; 697 AA.
AC G1KYN3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Neuronal PAS domain protein 4 {ECO:0008006|Google:ProtNLM};
GN Name=npas4 {ECO:0000313|Ensembl:ENSACAP00000021040.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000021040.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000021040.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000021040.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000021040.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_008103134.1; XM_008104927.1.
DR AlphaFoldDB; G1KYN3; -.
DR STRING; 28377.ENSACAP00000021040; -.
DR Ensembl; ENSACAT00000024989.3; ENSACAP00000021040.3; ENSACAG00000026720.3.
DR GeneID; 103277902; -.
DR KEGG; acs:103277902; -.
DR CTD; 266743; -.
DR eggNOG; ENOG502QRXX; Eukaryota.
DR GeneTree; ENSGT00530000064165; -.
DR HOGENOM; CLU_057591_0_0_1; -.
DR InParanoid; G1KYN3; -.
DR Proteomes; UP000001646; Chromosome 2.
DR Bgee; ENSACAG00000026720; Expressed in dewlap and 3 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF24; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF14598; PAS_11; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 53..106
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 133..192
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 291..326
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 481..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 77653 MW; 3BEB606A8D2A2A9D CRC64;
MQRRQFQTQA EEAERTMTIL CESCNKPIKR TENCILRCAA ATSVSRKELR IPKPFRSTKG
ASKARRDLIN AELQTLRSLL PISEQEKERL SYLHTMALVC FHIRETQLFP PDSFNTMRPV
PPLTSAAALM HPELLLSLPG FILALNGNHK LAYVSENVSH FLGFSVVELL AQGDSIFDLL
SSSASKVMQE KLCFAQQHPG TEIEFITEMC TSRAFRMKYK KSRSMLMRGR FIMSETQLTL
SSPALTFVAF CTPVAHAFDD EDSPSQNFAF QSKYTLDMKT AEITKNVVYH LGYQKEELIG
QSWYNLLHPE DAGRAAEMHR ALMHGAGKGT QSVVVRLLCK DLNWAWAQVV ASKENGQAGE
LITCTSWILR EEEAIHIKSQ DLQYGIVSQP SSNQIYYYGE VQNQTQGNEG NLYPQETAKT
RAGVLRFDPS QFPEVSAEKM ATASFEPLFP TNLPSMVDAG SLHSSHETGC PFFPDGLSCT
DQKDRQKSLS PSALYSPESS FSPDSSSSID FSPLLERGPS SGTFSEMDTS PDQDKWAISV
LAKQIHSLAE IFSQYTKERP QQPLDIALWP GLPVDHTHMA PRQSWGTDGA LDFLDEFSMD
EEVITSILSN LLHHDGLNQS TSVSGPEGNF HVSNPESELP LLQAPQTEAT LCFDQCSFMP
PFASSASAVS HVPDSQWDGT IHAELEQGIF HEEAMFC
//
