ID G1KZE2_ANOCA Unreviewed; 1273 AA.
AC G1KZE2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Zinc finger E-box binding homeobox 2 {ECO:0000313|Ensembl:ENSACAP00000021654.3};
GN Name=ZEB2 {ECO:0000313|Ensembl:ENSACAP00000021654.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000021654.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000021654.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000021654.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000021654.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger
CC family. {ECO:0000256|ARBA:ARBA00009867}.
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DR RefSeq; XP_008111186.1; XM_008112979.2.
DR AlphaFoldDB; G1KZE2; -.
DR STRING; 28377.ENSACAP00000021654; -.
DR Ensembl; ENSACAT00000026478.3; ENSACAP00000021654.3; ENSACAG00000023811.3.
DR GeneID; 100554209; -.
DR CTD; 9839; -.
DR eggNOG; KOG3623; Eukaryota.
DR GeneTree; ENSGT00950000183208; -.
DR HOGENOM; CLU_005890_0_1_1; -.
DR InParanoid; G1KZE2; -.
DR Proteomes; UP000001646; Chromosome 1.
DR Bgee; ENSACAG00000023811; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 6.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR008598; Di19_Zn-bd.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24391; HISTONE H4 TRANSCRIPTION FACTOR-RELATED; 1.
DR PANTHER; PTHR24391:SF18; ZINC FINGER PROTEIN 1; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF05605; zf-Di19; 1.
DR Pfam; PF12874; zf-met; 1.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 4.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 269..297
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 299..321
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 340..367
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 710..759
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 1057..1084
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1085..1112
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1113..1141
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DNA_BIND 712..760
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 113..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 890..916
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1174..1273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..916
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1215
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1216..1230
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1231..1273
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1273 AA; 142470 MW; 94BA7E1484E0FEC1 CRC64;
MRYIQETGTI RGGKIIRNNI SSAPLICSNI CGEVRGPRKH QGSPNVAVSV SQTPKFCPVC
LSAFANFCQS LRSPPKPGLQ TEVLNYENVV ETGSETDEED KLHIAEEDGI IGTLDQEPSP
ASVPNHESSP HVSQALMPRE EEEDDMRESG VDHTWHNNEI LQASVDGSEE MKEEYDTMGP
EAAIQTTGNN GTVKNANCTS DFEEYFAKRK LEEGDGHSVS IAEYLQRSDT AIIYPEAPEE
LSRLGTPEAN GQEENDLPPG TPDAFAQLLT CPYCDRGYKR LTSLKEHIKY RHEKNEENFP
CPLCNYTFAY RTQLERHMVT HKPGTDQHQM LTQGAGNRKF KCTECGKAFK YKHHLKEHLR
IHSGEKPYEC PNCKKRFSHS GSYSSHISSK KCIGLISVNG RMRNNIKTGS SPNSVSSSPT
NSAITQLRNK LENGKPLSMS EQSGLLKIKT EPLDFNEYKV LMATHGFTGA NPFMNGRLGA
TSPIGVHAPT QNPMQHLGMG MESPLLGFPA MGSNLSEVQK VLQIVDNTVS RQKMDCSSDE
ISKLKGYHMK DPCSQPEEQG VTSPGIPPVG LPVVSHNGAT KSIIDYTLEK VNEAKACLQS
LTTDSRRQLN NIKKEKLRTL IDLVTEDKMI ENHNIPTPFS CQFCKESFPG PIPLHQHERY
LCKMNEEIKA VLQPHENMAP SKQGVFVDKQ ALLLSSVLEK GMTSPINPYK DHMSVLKAYF
AMNMEPTSDE LLKISIAVGL PQEFVKEWFE QRKVYQFSTS RSPSLERSSA KVVLAATNNT
PMKDCLSARS PVKPVDSITS PSIAELHNSV TNCDTPLRLT KPTHFTNIKP VDKLDHSRSN
TPSPLNLSST SSKNSHSSSY TPNSFSSEEL QAEPLDLSLP KLMKEPKSII ATKNKTKSSS
VNVDHNSVSS SSETSDEPLN LTFIKKEFSN ANSLDKSTNP LFGMNPFSAK PLYTTLPPQS
AFPPATFMPP VQTSIPGLRP YPGIDQMSFL PHMAYTYPTG AATFADMQQR RKYQRKQGFQ
GELLDGTPDY MSGLDDMTDS DSCLSRKKIK KTESGMYACD LCDKTFQKSS SLLRHKYEHT
GKRPHQCQIC KKAFKHKHHL IEHSRLHSGE KPYQCDKCGK RFSHSGSYSQ HMNHRYSYCK
REAEEREAAE REAREKGHLE TTELLMNRAY LQSITPQGYS DSEERESMPR DGESEKEHEK
EGEDGFEKLG RRDGDEEFEE EEEEESENKS MDTDPDTIRD EEETGDHSMD DSSEDGKMET
KSDHEEDNME DGM
//
