ID G1L075_AILME Unreviewed; 984 AA.
AC G1L075;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=RAB44, member RAS oncogene family {ECO:0000313|Ensembl:ENSAMEP00000000277.2};
GN Name=RAB44 {ECO:0000313|Ensembl:ENSAMEP00000000277.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000000277.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000000277.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000000277.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_011216805.1; XM_011218503.2.
DR AlphaFoldDB; G1L075; -.
DR STRING; 9646.ENSAMEP00000000277; -.
DR Ensembl; ENSAMET00000000286.2; ENSAMEP00000000277.2; ENSAMEG00000000257.2.
DR GeneID; 100479050; -.
DR KEGG; aml:100479050; -.
DR CTD; 401258; -.
DR eggNOG; KOG0078; Eukaryota.
DR GeneTree; ENSGT00940000160379; -.
DR HOGENOM; CLU_012405_0_0_1; -.
DR InParanoid; G1L075; -.
DR TreeFam; TF313199; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0002553; P:histamine secretion by mast cell; IEA:Ensembl.
DR GO; GO:0097279; P:histamine secretion mediated by IgE immunoglobulin; IEA:Ensembl.
DR CDD; cd00154; Rab; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47977; RAS-RELATED PROTEIN RAB; 1.
DR PANTHER; PTHR47977:SF72; RAS-RELATED PROTEIN RAB-44; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 77..112
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..317
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..525
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 632..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..688
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..786
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 106439 MW; 7042898D9C3C0A78 CRC64;
MESGQRGPRK GRRLGSSRRW QMREPADGQD APVAPEPESL SSPVAAELQR FFQDCGAKER
GFVTREDLAA AKFSFLGGEE ELEMIFDWVD VEQKGRLSLE EFSSGLKNVF GSSLSTHRLH
RKRPLSSKRD SAATSFPVPE EADPEEKEAF FAFVQQLGAG HSLPEQAEIW QLWAKLRQEE
PQLAGSLEGF LATMSSRLQE VRADREVLEL TLRKRDSEHH QEVQQLHEEM EQQIRREKQQ
LQAESDSRGL AFSSQMQEVL EAKEHEFQQL MEGQRELEAQ LHGLRSSHRA ASSENQELRE
TERELAGRLE EARGQLRVTR GHLSAARGHA SWQVEEEPSV PRAGDEKAPD AQAVSSEEAP
LPGLFGEEDD WDQLLSDFNT SSRRALQLSW SPPPTPGTPS GPQTPRVVRQ ISISEPHAWL
LGQEPPSDLD GAPRSPSGAL SRTKEVKGVG PDGQDSGPEP PVQPRSLERK EESGPGPEAL
SHGSFPGAPT GESGSLVAAA LKMLVPLEDA PPPQLTAPPP QAPAGPSEQL QASHPDDKSL
GPGPVPEKAP RQSKALHQDP QVPGSETELG SPGAGALTPG LTGPSQDLEP VGQPPTEGLE
QGRLGPGVQE GPPGGLRDAH GWVLAPDGLP ALAHERLEED PGVEERKQVG QGGQDLSSEQ
SSEARGPAAG HSELPPRDHP PAPLPPEAPQ AQAQAEAPAP RTQPPPLDSP QEGAEPGGGA
GPQEHTQNPR TLVELEAQPL ASPTTARAEE QGSLPSREPP AENRPPDSGT DSGEAGPTSS
PGSPTASEPA ADPDYLFHVI FLGDSNVGKT SFLHLLHQNS FATGLTATVG VDFRVKTLLV
DHKCFALQLW DTAGQERYHS MTRQLLRKAD GVVLMYDITS WESFAHVRYW LDCLRESGPD
GVVLLLLGNK KDCEEERQVP TEVGQQLAQE LGVSFGECSA ALGHNILEPV VNLARSLKMQ
EDRLKGALVE MTPKRPQKRA GCCF
//
