ID G1L0Q0_AILME Unreviewed; 811 AA.
AC G1L0Q0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=DEP domain containing 1 {ECO:0000313|Ensembl:ENSAMEP00000000452.2};
GN Name=DEPDC1 {ECO:0000313|Ensembl:ENSAMEP00000000452.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000000452.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000000452.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000000452.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_002924706.1; XM_002924660.3.
DR AlphaFoldDB; G1L0Q0; -.
DR STRING; 9646.ENSAMEP00000000452; -.
DR Ensembl; ENSAMET00000000470.2; ENSAMEP00000000452.2; ENSAMEG00000000402.2.
DR GeneID; 100469692; -.
DR KEGG; aml:100469692; -.
DR CTD; 55635; -.
DR eggNOG; ENOG502QR00; Eukaryota.
DR GeneTree; ENSGT00950000182976; -.
DR HOGENOM; CLU_019607_0_0_1; -.
DR InParanoid; G1L0Q0; -.
DR TreeFam; TF328365; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0017053; C:transcription repressor complex; IEA:Ensembl.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR CDD; cd04405; RhoGAP_BRCC3-like; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR16206; DEP DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR16206:SF12; DEP DOMAIN-CONTAINING PROTEIN 1A; 1.
DR Pfam; PF00610; DEP; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 24..108
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
SQ SEQUENCE 811 AA; 93163 MW; 7C9124613DBBDB68 CRC64;
MESRTVPPGP YRATKLWNEI TTSFRAGMPL RKHRQHFKKY GNCFTAEEAV DWLYDLLRNN
NNFGPEVTRQ QTLQLLRKFL KNHIIEDIKG RWGSENLDDN SQLFRFPANS PLKSLPRRHP
ELRKNSIENF SKDKDSIFKL RNLSRRTPKK LGLHFSQENI EKMNHETISE DQENSIDNRE
RSQKDVEEVW RYIILIYLQT ILGVPSLEEL INPKQVVPQY VMYNMTNTSK HGIVILQDKS
DDLPHWVLSA MKCLANWSRS NDMNNPTYVG FERDVFRTIA DYFLDLPEPL LTFEYYELFV
SILVVCGYVT VSDRPSGIHK IQDDPQSSKI LRLNNLNSFK STECLLLSLL HKDKNKEESD
TTKRLQISDQ GFQEKCAKKM QLVNLKNRRA SANDIMGGSC HNLIGLGSMH VLSSNIKPRC
YSLEGIIDLP GSSSKEVFNV FHQSVLNKEG QNNQFLESKT KQESLMNLHS EESNQKSLCA
GFKRTSTLTV QDQEELCNGK CKSKQLCRSQ SLLLRSSTRR NSYINMPVAE IIMKPNLGQG
STSVQTAMES ELGESSTTIN KRFCKSTIEL SENSLPPASS VLTGTQSLLQ PHLERVAIDA
LQLCCLLLPP PNRRKLQLLM RMISRMSQNV DMPQLHDAMG TRSLMIHTFS RCVLCCAEEV
DLDELLAARL VSFLMDHHQE ILQVPSYLQT AVDKHLDYLK KGYIKNPGDG LIVPLPTYSY
CKQISAQEFD EQKVSTSQAA IAELLENIIK NKSLPLKEKR KKLKQFQKEY PLIYQKRFPT
TESEAVLFGD KPTIKQPMLI LKKPKFRSLR Y
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