ID G1L475_AILME Unreviewed; 1346 AA.
AC G1L475;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Adhesion G protein-coupled receptor F5 {ECO:0000313|Ensembl:ENSAMEP00000001685.2};
GN Name=ADGRF5 {ECO:0000313|Ensembl:ENSAMEP00000001685.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000001685.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000001685.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000001685.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
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DR STRING; 9646.ENSAMEP00000001685; -.
DR Ensembl; ENSAMET00000001751.2; ENSAMEP00000001685.2; ENSAMEG00000001585.2.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000154603; -.
DR HOGENOM; CLU_002753_3_5_1; -.
DR TreeFam; TF316380; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR45813:SF4; ADHESION G PROTEIN-COUPLED RECEPTOR F5; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00047; ig; 2.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1346
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030170531"
FT TRANSMEM 1014..1041
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1053..1075
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1095..1117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1129..1151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1171..1198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1219..1240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1246..1269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 166..273
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 274..366
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 471..561
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1012..1270
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1326..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1346 AA; 149334 MW; 6B968BBB51564151 CRC64;
MQSPRRTTLC FMIIGIYFSQ ATLNLKLESI VHPLILRERE LEGKEPLRQK RAVASSSPAA
EEYTVDVEIS FENASFLEPI KAYLHSLSFP IQGNSTDQAA NILSIEVTTV CRPTGNEIWC
SCETGYRWPQ ERCLQNLTCQ EHASAPAGHR CGCLKGLPPK GPFCQLQGDV TLRMSVRLNV
GFQEDLRNTS SALYRSYKTD LETAFWKGYS ILPGFKLVTV TGFRPGSVVV TYEVKTTTPS
PELMHKANEQ VMQNLNQTYK MDYSSFQAVT SNETKFTIIP EIIFEGDTVN LVCENEVLSS
NVSWHHIERR SDVQNTSRFS VYTTVLNNMT SVSRLTIYNI TQGDAGEYIC KLTLDIFEYE
SRKKIDVLPL RISAPEEMKV TCDNNPVSLN CCSEINANWS AIEWKQEGKI NIPGSPETDL
ESGCSRYTFR ADGTQCPSGL AGTTVIYVCE FVSTYGARGS KNIEVTFTSV ANLTITPDPI
SVSEGQNFSI KCISDVSNYD EVSWNTSAGI KIYQKFYTTR RSAAGTESVL TVKTATREWN
GTYHCIFRHK NSYSVAMKDV TVHPLPLEPD ILVDPLEATV PCKGSRHFRC CIKEDKDYKV
TFRMDSLSFL AEKEVNGKQV CYKYNFMASS VSWCPKKLDI FCHFTNAANH SVQSSSMKLN
LVPGEKIMCR DPTIGVGEPG KVIQKLCQFS NVPSGAERPT GGTMTYKCVG SRWEVKKNDC
ISAPINNLLQ LAKALTKSPC QDKKLPTYLR DLSVSTVKVK HEVSSFPGSL GAIINILDLL
STVPTQVNSE MMSNVLSTVN TILSKPMLST WKVFQKQQTN QSSQLLDSVE RFSRALRSED
SAFLSINQTN VQMRGMVIQP GHPKTYKQNF VFSDSDLWGN VAIDKCELGS LQWGSSIVTV
AFPTLKNILT QDGQGKNVAN SLVMTTTVNR NITMPFRISM TFKNTIPSGG VPQCVFWNFD
LANHTGGWDS SGCYVSRVDG DSVSCICDHL TSFSILMSPD SPYPGSLLEI LLDIISYIGL
CFSILSLAAC LVVEAVVWKS VTKNRTSYMR HTCIANIAAS LLVADIGFIV AAAIHDHFYP
LNETACVAAT FFIHLFYLSV FFWMLTLGLM VFYRLVFILH DASKSIQKTI AFSLGYGCPL
VISVITVGAT QPQEVYTRKN ACWLNWEDTK ALLAFVIPAL IIVVVNVTIT VVVISKILRP
SIGDKPSKQE KSSLFQISKS IGVLTPLLGL TWGFGLATVF QGSNAVFHII FTLLNAFQGL
FILLFGCLWD QKVQEALLKK FSLSRWSSQH SKSTSLGSST PVFSMSSPIS RRFNNLFGKT
GTYNVSTPET TSSSLENTSS AYSLLN
//
