ID G1L4L4_AILME Unreviewed; 461 AA.
AC G1L4L4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=Keratin, type II cytoskeletal 7 {ECO:0000256|ARBA:ARBA00039431};
DE AltName: Full=Cytokeratin-7 {ECO:0000256|ARBA:ARBA00042963};
DE AltName: Full=Keratin-7 {ECO:0000256|ARBA:ARBA00042887};
DE AltName: Full=Type-II keratin Kb7 {ECO:0000256|ARBA:ARBA00043134};
GN Name=LOC100481353 {ECO:0000313|Ensembl:ENSAMEP00000001824.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000001824.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000001824.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000001824.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit
CC EIF3S10. Interacts with GPER1. {ECO:0000256|ARBA:ARBA00038822}.
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DR AlphaFoldDB; G1L4L4; -.
DR STRING; 9646.ENSAMEP00000001824; -.
DR Ensembl; ENSAMET00000001899.2; ENSAMEP00000001824.2; ENSAMEG00000001683.2.
DR eggNOG; ENOG502QURK; Eukaryota.
DR GeneTree; ENSGT00940000161303; -.
DR HOGENOM; CLU_012560_5_4_1; -.
DR InParanoid; G1L4L4; -.
DR TreeFam; TF317854; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF21; KERATIN, TYPE II CYTOSKELETAL 7; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 93..461
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 369..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 97..223
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 303..369
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 383..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 51728 MW; 1F4F43767CD84222 CRC64;
MSIHLSSQVF SSRSSAFPGR GAQVRLSSVR PGTFSGSSSS LYSLGASRPR VAVRSAYGGP
VGAGIREVTI NQSLLAPLQV DIDPSIQQVR QEEREQIKTL NDKFASFIDK VRFLEQQNKL
LETKWALLQE QKSAKSSRLP SIFEAHIASL RRQLEGLQAD GGRLEVELRT MQGVVEDFKN
KYEDEINRRT AAENEFVVLK KDVDAAYMNK VELEAKVDAL SDEINFFKTF YEMELAELQA
QISDTSVVLS MDNSRSLDLD SIIAEVKAQY EEMANRSRAE AETMYQIKFE TLQAQAGKHG
DDLRNTRNEI TEMNRAIQRL QAEIDNIKNQ RAKLEAAIAE AEERGELAVK DANAKLAELE
AALQRAKQDH GPAAARVPGA HERQAGPGHR DRHLPQAAGG RGEPVGRRWS GHCEHLCGQL
RWRRGQWGGL RRNHGQQCPE LLEWQSWGLQ VLFHQDLNCH P
//
