ID G1L5G3_AILME Unreviewed; 4154 AA.
AC G1L5G3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Dynein axonemal heavy chain 6 {ECO:0000313|Ensembl:ENSAMEP00000002124.2};
GN Name=DNAH6 {ECO:0000313|Ensembl:ENSAMEP00000002124.2};
OS Ailuropoda melanoleuca (Giant panda).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX NCBI_TaxID=9646 {ECO:0000313|Ensembl:ENSAMEP00000002124.2, ECO:0000313|Proteomes:UP000008912};
RN [1] {ECO:0000313|Ensembl:ENSAMEP00000002124.2, ECO:0000313|Proteomes:UP000008912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20010809; DOI=10.1038/nature08696;
RA Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA Wang J.;
RT "The sequence and de novo assembly of the giant panda genome.";
RL Nature 463:311-317(2010).
RN [2] {ECO:0000313|Ensembl:ENSAMEP00000002124.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR RefSeq; XP_002922903.1; XM_002922857.3.
DR STRING; 9646.ENSAMEP00000002124; -.
DR Ensembl; ENSAMET00000002214.2; ENSAMEP00000002124.2; ENSAMEG00000002004.2.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154761; -.
DR HOGENOM; CLU_000038_3_1_1; -.
DR InParanoid; G1L5G3; -.
DR TreeFam; TF352520; -.
DR Proteomes; UP000008912; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF34; DYNEIN HEAVY CHAIN, CYTOPLASMIC; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008912}.
FT DOMAIN 1460..1563
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 1741..1882
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2084..2233
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2435..2593
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 127..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 346..373
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2908..2949
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 132..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4154 AA; 476365 MW; FBDA8E06FC789F97 CRC64;
MAFHTSEKDI ELKNIEELVE NPALARLNSI TAKGRLSFVV PTENESDTQF LTFSHITKAQ
ERTRKRQQPI KLEPLPVLKV YQDHKRPEYI YEQNRLRLIT SGILKAPRST EERGSAKVSI
QFPEHQGPMV KKKQIPQSST EMFAPSPKLS RTGIGRRGLY GTSSSAYPKY IFHDREEVIK
ANIRNPLQII KIIRENEHLG FLYMIPAVPR SSIEYDTYNL KVVSYENINK NDYYTISKKA
VTHTYNEELE YIEIDRWEQE YLYHRELTKI PIFALFRKWK AFNVWKKNVR SKKISGCRKS
LQKNLFIINH YLRPALLKIN ELCYHLSFMG LCHIEKCHTY TLQEFKVAQV IRLKEVTERL
EEFRNEAKNV VRKACQIALR AEGFIPDDCL HKSAEDYCKI QDGGGLTELP AYTDSDKMTY
TEQASKRHHC MRLTCFIRLN DYLIENTMHV LTVNSVNSLL NYLTDKLKRT PSADVIQKWI
TEEKTEVTEK KVTSVGEKQE EDESLIPMFL TELILTVQSL LFEPSLEDFL DGISGAINHF
QNTVLSVPNL VPDTYFDAFT RPYINNKLEE KTCGSGPSLS AVFDDDKNFR TIIFQIKETI
QAAFESARLY AATFEKFQIF FKENESLDLQ ALKLQEPDVE FFREQLEKYH RQHKDAVALK
PTRNVGLLLV DTKLLKEKLI PSPLRCLEVL NYMLPCQSKK KVDAIISEAQ DAEYKLEFVP
TTTIEYVNSL VFLDEIQERI ESLEDEGNVV IQMYKLIEQY QVPTPPEDFA VFATMKPSII
AVRNAIDKSV GDRETRIKQF SQHLGRDLED LTNEVNEVKL QAQDPQILDI TADQDKIKLT
LSELQVVLDD LQKRAFQYKS YQKNFKVEVS KFETLEEVSA ELKLKQLLWD SLSEWDHLQQ
EWLKSKFDCL DPEFLNSQVS KYAKFVTQLE KGLPPNSVVP QLKHKVEKMK EKLPVIIDLR
NPTLKARHWA AIEQTVDASL VGLEIPLTLQ KLSELRVFDF GQEIQDISGQ ASGEAALEII
LKKVEDSWKT TEFIVLPHRD SKDVFILGGT DDIQVLLDDS TINIATIASS RYVGPLKMRV
DDWQKQLALF NQTLEEWLNC QRNWLYLESI FNAPDIQRQL PAEAKMFLQV DKSWKEIMRK
VNRLPNALRA ATQPGLLETF QNNNALLDQI QKCLEAYLES KRVIFPRFYF LSNDELLEIL
AQTRNPQAVQ PHLRKCFDAI SKLEFALMPP TEGKIPGVEG EPEKIYTNDI LAMLSPEGER
VSLGKGLKAR GNVEEWLGKV EEAMFTSLRR LCKAAIADYQ GKPRTDWVIA GHPSQVILTI
SQIMWCRDLT ECLEKEDGNH VEALEEFEKV NFERLNALAV IVRGSLPKLH RNIITALITI
DVHARDIVTE LVQAKVEEVD SFDWQRQLRY YWDVDLDNCV ARMALSQYTY GYEYLGACPR
LVITPLTDRC YLCLMGALQL DLGGAPAGPA GTGKTETTKD LAKALAIQCV VFNCSDGLDY
KMMGRFFSGL AQSGAWCCFD EFNRIDIEVL SVIAQQLITI RNAKAAKLSR FMFEGREIKL
VMTCAAFITM NPGYAGRTEL PDNLKALFRP FAMMVPNYAL IAEVILYSEG FESSKILARK
MTQMYKLCSE QLSQQDHYDF GMRAVKSVLV MAGSLKRENP DLSEDVVLIR ALRDSNLPKF
LTDDALLFSG IISDLFPGVQ IPEHDYGILQ STIIDVMNRQ NLQPETCMVK KVIQFYETML
VRHGVMLVGP TGGGKTTVYQ ILAETLGNLR KLGIDNPFYQ PVKTYVLNPK SITMGELYGE
VNNITLEWKD GLMALSVRAA VNDTSEDHKW IISDGPVDAL WIENMNTVLD DNKMLCLANS
ERIKLTPQIH MLFEVQDLRV ASPATVSRCG MVFVDPEELK WMPYVKTWMQ SISKKLNEET
QEYILKLFQR YVDDGLYFIN KKCGQAIPQV DISKVTTLCC LLQSLILGKD GVNLTMEQAK
LNTMLCQTFV FCYLWSLGGN LTENYWDSFD TFIRTQFDDN PDARLPSSGD LWSIYMDFDT
KRLDPWERII PTFKYSRDVP FFETLVPTTD TVRFGYLMEK LLAVRHSVLF TGITGVGKSV
IAKGLLNRIQ ESAGYVPVYL NFSAQTSSAR TQEIIESKLE RKRKNILGAP GNKQVVIFVD
DLNMPRLDRY GSQPPIELLR QYQDFGGFYD RSKLFWKDIQ DVTIVSACAP PGGGRNPVTP
RFIRHFSMLC LPLPSEHSLK QIFQAILNGF LSDFPPAVKQ TASNIVEAAV EIYNRMSVDL
LPTPAKSHYV FNLRDLSKCV QGILQCDPGT IREEIQIFRL FCHECQRVFH DRLINNEDKH
YFHTILTEMA NKHFGIAIGL EYFLNRPIIF GDFIKFGADK IDRIYDDMPD MEKIANVLED
YLDDYNLINP KEVKLVFFQD AIEHVSRIAR MIRQERGNAL LVGVGGTGKQ SLTRLAAHIC
GYKCLQIELS RGYNYDSFHE DLRKLYKLAG VDDRNMVFLF TDTQIVVEEF LEDINNVLNS
GEVPNLFEKD ELEQVLAATR PRAKEVGISE GNRDEVFQHF ISRVRQKLHI VLCMSPVGEA
FRSRCRMFPS LVNCCTIDWF VQWPREALLS VSKTFFANVD AGKEELKEKL SLMCVNIHLS
VSTMAERYYA ELRRRYYTTP TSYLELINLF LTMLSEKRKQ LVSARDRVKN GLTKLLETNV
LVDKMKLELS ALEPVLYQKS QDVEALMDKL AVDQENADQV RSIVQEDEAT AKVKAQETQA
IADDAQRDLE EALPALDAAN RALDSLDKAD ISEIRVFTKP PDLVMTVMEA ISILLNAKPD
WPTAKQLLGD SNFLRRLLEY DKENIKPQIL AKLQKYINNP DFVPEKVEKV SRACKSMCMW
VRAMDLYSRV VKEVEPKRQK LRAAQAELDI TMATLREKQA LLKQVEDQIQ ALQDEYDKGV
NEKESLAKTM TLTKARLIRA GKLTAALGDE QVRWEESIQK FNEEISNVIG NVFIAAACVA
YYGAFTAQYR QSLIEYWIQD CLSLEIPINP SFSLINILGD PYEIRQWNTD GLPRDIISTE
NGILVTQGRR WPLMIDPQDQ ANRWIRNKES KSGLKIIKLT DSNFLRTLEN SIRLGLPVLL
EELKETLDPA LEPILLKQTF MSGGRLLIHL GDSDIDYDKN FRFYMTTKLP NPHYLPEVCI
KVTIINFTVT KSGLEDQLLS DVVRLEKPEL EEQRIKLIVR INADKNQLKT IEEKILRMLF
TSEGNILDNE ELIDTLQDSK ITSGAIKIRL KEAESTEVMI NIAREKYRPV ATQGSVMYFV
IASLSEIDPM YQYSLKYFKQ LFNTTIETSL RTDDLQQRLE ILLEQTLLTT YINVSRGLFE
QHKLIYSFML CVEIMRQQEN LTDVEWNFFL RGSAGLEKER PPRPDVPWLH PAMWFACCDL
EESFVVFKGL TQYILLQPIS IRIGSFETYI NPAEWGGYSK MKPEEEFMTQ EKEIKSHDSW
HPVLSSFQKL ILIKCCKEEK VVFALTDFVI ENLGKRFIET PPVDLPTLYQ DMSYNTPLVF
ILSTGSDPMG AFQRFARESG YSERVQSISL GQGQGPIAER MIKEAMKSGN WVFLQNCHLA
VSWMLAMEEL IKTFTDPTIT IKDTFRLFLS SMPSSTFPVT VLQNSVKVTN EPPKGLRANI
RRAFTEMTPS FFEENILGRK WRQIIFGICF FHAIIQERKK FGPLGWNICY EFNDSDRECA
LLNLNLYCQE GKIPWDALIY ITGEITYGGR VTDTWDQRCL RTVLKRFFSP ETLEEDYKYS
ESGIYFAPLA DSLQEFKDYI ENLPLMDDPE IFGMHENANL VFQYKETNTL INTILEVQPR
SSSGGEGKSN DEIVQELVAS VQTRVPETLE MENASESLFV KDPHGRLNSL TTVLGQEVDR
FNKLLKLIHT SLETLNKAIA GFVVMSEEME KVYNSFLNNQ VPSLWSSTAY PSLKPLGSWV
KDLILRTAFV ELWLKRGQPK SFWISGFFFP QGFLTGTLQN HARKYNLPID ELSFKYNMIS
AYRDQAAVIE AARTVQFGQE LPMDLELPSP EDGVLVHGMF MDASRWDNTE MVIEDALPGQ
MNPMLPVVHF EPQQNYVPDP TLYHSPLYKT GARAGTLSTT GHSTNFVVTV LLPSKRSKDY
WIAKGSALLC QLNE
//
